Hypothalamic and Pituitary Diseases, Genetics
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Hair ▶Skin and Hair
Hairpin Ribozyme Definition A hairpin ribozyme can cleave oligoribonucleotides at specific sites, GUC. ▶Catalytic RNA
Hair Bulge Definition Hair bulge is that part of the outer root sheet of the hair follicle that is located above the insertion of the arrector pili muscle. It corresponds to the lowest non-cycling part of the hair follicle and contains multipotent skin stem cells. ▶Skin and Hair
Hair Matrix Definition Hair matrix consists of transit-amplifying, epithelial cells that are located at the base of the hair follicle, the hair bulb. The progeny of hair matrix cells withdraw from the cell cycle and move upwards in cellular cohorts while undergoing terminal differentiation. ▶Skin and Hair
Hairpin End
Half-Life Definition Half-life defines the time required to decrease the concentration of a substance/drug to the half of its original value. ▶Biochemical Engineering of Glycoproteins
Hamartoma Definition Hamartoma is a benign outgrowth of tissue composed of normally differentiated cells and matrix components typical for that site without signs of dysplasia. ▶Peutz-Jeghers Syndrome ▶Tuberous Sclerosis
Hammerhead Ribozyme Definition
Definition Hairpin end refers to the end of a DNA double strand that is sealed in the form of a hairpin by the covalent linkage of the 5′ strand to the 3′ strand. ▶DNA Recombination
Hammerhead ribozymes can cleave oligoribonucleotides at specific sites, e.g. NUX, where N and X are A, G, C, U and A, C, U, respectively, with most efficient cleavage at GUC triplets. ▶Catalytic RNA
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Haploid
Haploid
Haplotype Block
Definition
Definition
The term haploid describes a cell that has only a single copy of each chromosome (e.g. post-meiotic germ cells). ▶Mutagenesis Approaches in the Zebrafish
Haplotype block is a section of the genome around 25 kilo bases showing minimal diversity amongst individuals of the same ethnic group. ▶Genetic Predisposition to Multiple Sclerosis
Haploid Analysis Definition Haploid analysis refers to an analysis technique aimed at separating two paternal and maternal chromosome pairs into two different cell lines. Haploid analysis makes it possible to separately detect a mutation in each chromosome. ▶Spinal Muscular Atrophy
Hapten Definition Hapten refers to a small molecule that reacts with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other large antigenic molecule. ▶Protein Microarrays as Tool for Protein Profiling and Identification of Novel Protein-Protein Interactions
Haploinsufficiency Definition Haploinsufficiency describes the situation in which an individual, who is heterozygous for a certain gene ▶mutation or ▶hemizygous at a particular ▶locus, is clinically affected because the protein produced by a single copy of an otherwise normal gene is not sufficient to assure normal function. ▶Bone and Cartilage ▶Hereditary Diseases Genetic Basis ▶Homeodomain Transcription Factors ▶Mouse Genomics ▶Protein/DNA Interaction ▶Replication Fork
Haplotype
Harker Section Def
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