Hypoxia Translation in Progress
The latest in a series of books from the International Hypoxia Symposia, this volume spans reviews on key topics in hypoxia, and abstracts from poster and oral presentations. The biannual International Hypoxia Symposia are dedicated to hosting the best ba
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Robert C. Roach Peter D. Wagner Peter H. Hackett Editors
Hypoxia Translation in Progress
Advances in Experimental Medicine and Biology Volume 903 Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy
More information about this series at http://www.springer.com/series/5584
Robert C. Roach • Peter D. Wagner Peter H. Hackett Editors
Hypoxia Translation in Progress
Editors Robert C. Roach Director, Altitude Research Center University of Colorado Anschutz Medical Center Aurora, CO, USA
Peter D. Wagner Division of Physiology 0623A University of California - San Diego La Jolla, CA, USA
Peter H. Hackett Director, Institute for Altitude Medicine Telluride, CO, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-1-4899-7676-5 ISBN 978-1-4899-7678-9 (eBook) DOI 10.1007/978-1-4899-7678-9 Library of Congress Control Number: 2016937490 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Contents
Part I 1
2
3
4
Epigenetic Mechanisms as an Interface Between the Environment and Genome ............................................................................................. Zdenko Herceg Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans ................... Claudio Sartori, Stefano F. Rimoldi, Hervé Duplain, Thomas Stuber, Sophie Garcin, Emrush Rexhaj, Yves Allemann, and Urs Scherrer Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications ...
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