Image-based stroke rat brain atrophy volume and infarct volume computation
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Image‑based stroke rat brain atrophy volume and infarct volume computation Yung‑Kuan Chan1 · Chun‑Fu Hong2 · Meng‑Hsiun Tsai1 · Ya‑Lan Chang1 · Ping‑Hsuan Sun1
© The Author(s) 2020
Abstract Stroke is one of the leading causes of death as well as results in a massive economic burden for society. Stroke is a cerebrovascular disease mainly divided into two types: ischemic stroke and hemorrhagic stroke, which, respectively, refer to the partial blockage and bleeding inside brain blood vessels. Both stroke types lead to nutrient and oxygen deprivation in the brain, which ultimately cause brain damage or death. This study focuses on ischemic stroke in rats with middle cerebral artery occlusion (MCAO) as experimental subjects, and the volumes of infarct and atrophy are calculated based on the brain slice images of rat brains stained with 2,3,5-triphenyl tetrazolium chloride. In this study, a stroke rat brain infarct and atrophy volumes computation system (SRBIAVC system) is developed to segment the infarcts and atrophies from the rat brain slice images. Based on the segmentation results, the infarct and atrophy volumes of a rat brain can be computed. In this study, 168 images of brain slices cut from 28 rat brains with MCAO are used as the test samples. The experimental results show that the segmentation results obtained by the SRBIAVC system are close to those obtained by experts. Keywords Stroke · Middle cerebral artery occlusion (MCAO) · 2,3,5-Triphenyl tetrazolium chloride (TTC) · Brain infarct · Brain atrophy
1 Introduction Stroke is now the leading cause of acquired adult disability worldwide [29]. Stroke is caused mainly by the internal cerebrovascular obstruction or hemorrhagic that causes the brain lack of nutrient and oxygen, leading to brain injury or Chun-Fu Hong and Meng-Hsiun Tsai have equal contribution to this article. The two authors are listed based on their surname. * Yung‑Kuan Chan [email protected] Extended author information available on the last page of the article
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death eventually. Stroke is classified majorly into two types: ischemic stroke and hemorrhagic stroke, in which ischemic stroke accounts for 70–80% of all stroke incidences. According to the statistics of World Health Organization (WHO), there were about 15.2 million people died of stroke and ischemic heart disease in 2016 and these diseases are still the leading causes of death over the last decade [42]. In 2013, global prevalence of stroke was 25.7 million, in which 10.3 million people suffered first attack [10]. In the USA, stroke ranked as No. 5 among all causes of death in 2014 and is also a leading cause of long-term disability and cognitive impairment; according to the estimates in 1999, there were about 795,000 American experienced a new or recurrent stroke, in which 610,000 people were first attacks and others were recurrent incidences [4]; according to the data during 2011–2014, the overall stroke prevalence was estimated 7.2 million American over 20 years of age, accounting f
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