Imipramine
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Dystonia in a child: case report An 8-year-old boy developed dystonia while receiving imipramine for major depression. The boy was diagnosed with a major depressive episode, and started on imipramine 25 mg/day [route not stated]. Three months later, he presented with involuntary dystonic movements characterised by sideways turning of the neck, twisted facial muscles and mouth opening. He reported no urge to perform these movements, which were painful and significantly interfered with basic activities, such as eating and drinking. Imipramine was his only medication, and a diagnosis of transient drug-induced dystonia was made. Imipramine was immediately withdrawn. The dystonia persisted for more than 2 days after the last imipramine intake; he remained free of abnormal movements over 1 year of follow-up. Author comment: "The case described in this report represents a rare consequence of a tricyclic antidepressant". Freitas FAC, et al. Imipramine-induced dystonia in a child: A case report. Revista Brasileira de Psiquiatria 34: 497-500, No. 4, Dec 2012. Available from: URL: 803085515 http://dx.doi.org/10.1016/j.rbp.2012.04.005 - Brazil
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Reactions 13 Apr 2013 No. 1447
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