Immune Cells Within the Tumor Microenvironment
A plethora of intrinsic and extrinsic factors, including communication between tumorigenic cells and infiltrating immune cells, fibroblasts, epithelial cells, vascular and lymphatic endothelial cells, cytokines and chemokines, constitute the tumor microen
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Interaction of Immune and Cancer Cells
Interaction of Immune and Cancer Cells
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Magdalena Klink Editor
Interaction of Immune and Cancer Cells
Editor Magdalena Klink Polish Academy of Sciences Institute of Medical Biology Lodz Poland
ISBN 978-3-7091-1299-1 ISBN 978-3-7091-1300-4 (eBook) DOI 10.1007/978-3-7091-1300-4 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2013954999 © Springer-Verlag Wien 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The tumor microenvironment is a dynamic network that consists of tumor cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines, chemokines, and receptors. Every element of this network promotes neoplastic transformation and supports tumor growth and invasion, as well as protecting the tumor from host immunity. A full understanding of the mechanisms underlying tumor growth and progression requires the thorough study of the above-mentioned factors and cells within the tumor microenvironment. The main purpose of this book is to summarize the knowledge concerning the interactions of various types of cells in the solid tumor microenvironment, as the main factors involved in tumor progression and metastasis. Infiltratin
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