Immuno-compatibility of desaminotyrosine and desaminotyrosyl tyrosine functionalized star-shaped oligo(ethylene glycol)s
- PDF / 300,423 Bytes
- 6 Pages / 432 x 648 pts Page_size
- 75 Downloads / 191 Views
,PPXQRFRPSDWLELOLW\RIGHVDPLQRW\URVLQHDQGGHVDPLQRW\URV\OW\URVLQHIXQFWLRQDOL]HG VWDUVKDSHGROLJR HWK\OHQHJO\FRO VZLWKGLIIHUHQWPROHFXODUZHLJKWV 7RUDOI5RFK.RQVWDQ]H.-XOLFK*UXQHU$[HO71HIIH1DQ0D$QGUHDV/HQGOHLQ
,QVWLWXWHRI%LRPDWHULDO6FLHQFHDQG%HUOLQ%UDQGHQEXUJ&HQWHUIRU5HJHQHUDWLYH7KHUDSLHV %&57 +HOPKROW] =HQWUXP*HHVWKDFKW.DQWVWU7HOWRZ*HUPDQ\ +HOPKROW]9LUWXDO,QVWLWXWHí0XOWLIXQFWLRQDO%LRPDWHULDOVIRU0HGLFLQH7HOWRZDQG%HUOLQ*HUPDQ\ ,QVWLWXWHRI&KHPLVWU\DQG%LRFKHPLVWU\'HSDUWPHQWRI%LRORJ\&KHPLVWU\DQG3KDUPDF\)UHLH8QLYHUVLWlW %HUOLQ7DNXVWU %HUOLQ*HUPDQ\
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ȕDQG,/ZHUHGHWHFWHGIRUDOOV2(*VROXWLRQVEXWRQO\ZKHQXVHG DWFRQFHQWUDWLRQVDERYHJāP/)XUWKHUPRUHRQO\WKHN'DV2(*'$7LQGXFHGORZ DPRXQWVRI526SURGXFLQJPRQRF\WHV&RQFOXVLYHO\WKHGDWDLQGLFDWHWKDWWKHPDWHULDOVZHUH QRWFRQWDPLQDWHGZLWKPLFURELDOSURGXFWVDQGGRQRWLQGXFHVXEVWDQWLDOLPPXQRORJLFDODGYHUVH HIIHFWVin vitro, ZKLFKLVDSUHUHTXLVLWHIRUIXWXUHELRORJLFDODSSOLFDWL
Data Loading...
