Immunoglobulin G
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Aseptic meningitis: case report A 14-year-old girl received human IV immunoglobulin G (400 mg/kg of body weight daily) for 5 days for idiopathic thrombocytopenia. Two days following the final immunoglobulin G infusion, she developed a fever, headache, vomiting and photophobia. On examination, she displayed drowsiness, neck stiffness, and a temperature of 39.5°C. Laboratory analysis revealed a WBC count of 18 400/mm3, and a CSF cell count of 140 leucocytes/mm3 with 30% lymphocytes and 70% neutrophils. Findings were consistent with a diagnosis of aseptic meningitis. Treatment with floctafenine was initiated. Immunoglobulin G therapy was discontinued and her symptoms resolved within 3 days. Author comment: "[B]ased on the Naranjo algorithm, it is probable that aseptic meningitis in our patient was due to human intravenous IgG." Chaabane A, et al. Human intravenous immunoglobulin-induced aseptic meningitis: A case report. Journal of Clinical Pharmacology 52: 279-281, No. 2, Feb 2012. Available from: URL: http://dx.doi.org/10.1177/0091270010394183 803068963 Tunisia
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Reactions 7 Apr 2012 No. 1396
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