Immunoglobulin
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Immunoglobulin Haemolysis: 3 case reports
In a case series, 3 patients (1 man and 2 woman) aged 20–75 years were described, who developed haemolysis during treatment with immunoglobulin for myasthenia gravis or Guillain–Barre syndrome [dosages not stated]. Patient 1: A 75-year-old man presented with dysarthria and shortness of breath due to myasthenia gravis. Therefore, he was initiated on IV immune globulin [IVIG] for 4 days. However, he developed haemolytic anaemia along with 3g decrease in haemoglobin [duration of treatment to reaction onset not stated]. Subsequently, he was treated with folic acid and packed red blood cells transfusion [outcome not stated]. Patient 2: A 59-year-old woman with myasthenia gravis received 5 days treatment with IV immune globulin along with rituximab. Her condition improved and she was discharged, but 7 days later, she returned to emergency department due to shortness of breath. Her Hb dropped and after receiving treatment, a subsequent improvement in her condition was noted. Patient 2: A 20-year-woman was admitted with a presumed diagnosis of Guillain–Barre syndrome. She received a 4 day treatment with IV immune globulin. On day 5, her Hb level fell to 9 g/dL. After receiving treatment, a subsequent improvement in her condition was noted. Chadha J, et al. IVIG-induced abrupt hemolysis in neurological conditions. Blood 134 (Suppl. 1): 4991, 13 Nov 2019. Available from: URL: http://doi.org/10.1182/ blood-2019-124508 [abstract]
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Reactions 18 Jan 2020 No. 1787
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