Immunology of the Skin Basic and Clinical Sciences in Skin Immune Re
This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimul
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Immunology of the Skin Basic and Clinical Sciences in Skin Immune Responses
Immunology of the Skin
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Kenji Kabashima Editor
Immunology of the Skin Basic and Clinical Sciences in Skin Immune Responses
Editor Kenji Kabashima Department of Dermatology Kyoto University Graduate School of Medcine Sakyo-ku, Kyoto Japan
ISBN 978-4-431-55853-8 ISBN 978-4-431-55855-2 DOI 10.1007/978-4-431-55855-2
(eBook)
Library of Congress Control Number: 2016932894 Springer Tokyo Heidelberg New York Dordrecht London © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Japan KK is part of Springer Science+Business Media (www.springer.com)
Preface
The skin is one of the largest organs of our body and is continuously exposed to a variety of external stimuli, such as bacteria, viruses, fungi, ultraviolet light, chemicals, dryness, haptens, and protein antigens. Thus, the skin is an important barrier between the living organism and its environment to maintain our homeostasis. Defending physically against external stimuli, the skin is also an immunological defense. The immune capacity of the skin involves several cell types: Langerhans cells, dermal dendritic cells, T cells, endothelial cells, keratinocytes, mast cells, basophils, and other cells, all of which participate under certain circumstances in a harmonious manner. Thus, the concept of skin-associated lymphoid tissue (SALT) was proposed in the early 1980s. As a result of immune responses to external stimuli, several inflammatory skin diseases are induced. Therefore, understanding the skin immune responses is essential not only to basic scientists including immunologists but also to clinicians, such as allergologists and dermatologists. For this book, I prepared two major parts: I. Components of Skin Immune Cells, and II. Immune Systems in the Skin. This thematic division will make the book easily understood by readers. In addition, I have tried to cover each topi
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