Immunotherapy for Gastrointestinal Cancer
This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy.Starting by introduc
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David Kerr Rebecca Johnson Editors
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Immunotherapy for Gastrointestinal Cancer
David Kerr • Rebecca Johnson Editors
Immunotherapy for Gastrointestinal Cancer
Editors David Kerr Nuffield Division of Clinical and Laboratory Sciences University of Oxford Oxford UK
Rebecca Johnson John Radcliffe Hospital Oxford University Hospitals NHS Trust John Radcliffe Hospital Oxfordshire UK
ISBN 978-3-319-43061-4 ISBN 978-3-319-43063-8 (eBook) DOI 10.1007/978-3-319-43063-8 Library of Congress Control Number: 2016961520 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Introduction to Modern Immunology�������������������������������������������������������� 1 Rachel Kerr 2 Cell Based Therapy: Modified Cancer Cells ������������������������������������������ 23 Vanessa Deschoolmeester, David Kerr, Patrick Pauwels, and Jan B. Vermorken 3 Therapeutic Cancer Vaccines ������������������������������������������������������������������ 47 Chris Heery, Anteneh Tesfaye, Benjamin Weinberg, and John Marshall 4 Antibody Drug and Radionuclide Conjugates for GI Cancers������������� 79 Beverly A. Teicher 5 Antibodies that Inhibit Specific Cellular Pathways in Gastric Cancer ������������������������������������������������������������������������������������ 101 Do-Youn Oh and Yung-Jue Bang 6 PD1 and PD-L1 Immune Checkpoint Inhibitors in Gastrointestinal Cancer���������������������������������������������������������������������� 115 Eirini Pectasides and David McDermott 7 The Role of the JAK/STAT Signalling Pathway in Immunoregulation of Gastrointestinal Cancers ������������������������������ 147 Kris Vaddi 8 Hypermutated Colorectal Cancer and Neoantigen Load�������������������� 187 M
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