Impact of high-dose statin on cardiovascular outcomes in real-world patients with ST-elevation acute myocardial infarcti
- PDF / 1,908,919 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 14 Downloads / 174 Views
ORIGINAL ARTICLE
Impact of high‑dose statin on cardiovascular outcomes in real‑world patients with ST‑elevation acute myocardial infarction Takenobu Shimada1 · Kohei Osakada1 · Koya Okabe1 · Yuki Shima1 · Haruki Eguchi2 · Seiji Habara1 · Takeshi Tada1 · Yuya Taguchi1 · Akihiro Ikuta1 · Makoto Takamatsu1 · Ryosuke Murai1 · Katsuya Miura1 · Masanobu Ohya1 · Hidewo Amano1 · Shunsuke Kubo1 · Hiroyuki Tanaka1 · Takeshi Maruo1 · Yasushi Fuku1 · Harumi Katoh1 · Tsuyoshi Goto1 · Kazushige Kadota1 Received: 11 June 2020 / Accepted: 28 August 2020 © Springer Japan KK, part of Springer Nature 2020
Abstract Little is known about the impact of a high-dose statin on cardiovascular outcomes after ST-elevation acute myocardial infarction (STEMI) in real-world Japanese patients. Between July 2011 and June 2017, 1110 consecutive STEMI patients underwent primary percutaneous coronary intervention at our hospital and were discharged. A high-dose statin was administered in 117 patients (10.5%) and non-high-dose statin was administered in 947 patients (85.3%). The low-density lipoprotein cholesterol level was significantly higher in the high-dose statin group at admission (129.8 ± 44.9 vs. 110.4 ± 32.7, p 0.99 0.87 0.84
0.89 0.71 0.65 0.34 0.95 0.71
0.45
> 0.99 0.12 0.002
Heart and Vessels Table 1 (continued)
3rd DES, n (%) BMS, n (%) PCB, n (%) POBA, n (%) 2nd or 3rd DES, n (%) TIMI grade at pre-procedure 3/2/1/0, n (%) TIMI grade 0 at pre-procedure TIMI grade at post-procedure 3/2/1/0, n (%)
Total n = 1064
High-dose statin n = 117
Non-high-dose statin n = 947
103 (9.7) 58 (5.5) 5 (0.5) 11 (1.0) 990 (93.0)
21 (18.0) 3 (2.6) 2 (1.7) 0 (0.0) 112 (95.7)
82 (8.7) 55 (5.8) 3 (0.3) 11 (1.2) 878 (92.7)
109 (10.2)/222 (20.9)/100 (9.4)/633 (59.5) 633 (59.5)
8 (6.8)/18 (15.4)/13 (11.1)/78 (66.7) 78 (66.7)
101 (10.7)/204 (21.5)/87 (9.2)/555 (58.6) 555 (58.6)
109 (93.2)/7 (6.0)/1 (0.9)/0 (0.0) 8 (6.8)
854 (90.2)/84 (8.9)/6 (0.6)/3 (0.3) 93 (9.8)
0.40
7 (7–10)
7 (7–11)
0.34
52.2 ± 7.8
52.1 ± 9.7
0.86
116 (99.2) 116 (99.1) 5 (4.3) 85 (72.7) 104 (86.6) 5 (4.3) 9 (7.7)
945 (99.8) 939 (99.2) 94 (9.9) 606 (64.0) 817 (86.3) 4 (0.4) 36 (3.8)
0.30 > 0.99 0.04 0.07 0.56 0.001 0.08
32 (27.4) 23 (19.7) 0 (0.0)
187 (19.8) 138 (14.6) 4 (0.4)
0.07 0.17 > 0.99
71.8 ± 21.7 116.7 (56.8–263.5) 13.1 ± 1.6 5.9 (5.4–6.5) 0.30 (0.21–0.44) 0.820 (0.482–1.463)
67.7 ± 24.9 134.6 (53.5–284.5) 12.5 ± 1.9 5.8 (5.5–6.4) 0.34 (0.25–0.47) 0.978 (0.365–2.014)
0.06 0.13
Data Loading...
