Prognostic impact of admission high-sensitivity C-reactive protein in acute myocardial infarction patients with and with
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ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
Prognostic impact of admission high‑sensitivity C‑reactive protein in acute myocardial infarction patients with and without diabetes mellitus Claudia Lucci1, Nicola Cosentino1, Stefano Genovese1, Jeness Campodonico1, Valentina Milazzo1, Monica De Metrio1, Maurizio Rondinelli1, Daniela Riggio1, Maria Luisa Biondi1, Mara Rubino1, Katia Celentano1, Alice Bonomi1, Nicolò Capra1, Fabrizio Veglia1, Piergiuseppe Agostoni1,2, Antonio L. Bartorelli1,3 and Giancarlo Marenzi1*
Abstract Background: High-sensitivity C-reactive protein (hs-CRP) elevation frequently occurs in acute myocardial infarction (AMI) and is associated with adverse outcomes. Since diabetes mellitus (DM) is characterized by an underlying chronic inflammation, hs-CRP may have a different prognostic power in AMI patients with and without DM. Methods: We prospectively included 2064 AMI patients; hs-CRP was measured at hospital admission. Patients were grouped according to hs-CRP quartiles and DM status. The primary endpoint was a composite of in-hospital mortality, cardiogenic shock, and acute pulmonary edema. Two-year all-cause mortality was the secondary endpoint. Results: Twenty-six percent (n = 548) of patients had DM and they had higher hs-CRP levels than non-DM patients (5.32 vs. 3.24 mg/L; P
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