Impact of postoperative complications on outcomes of second surgery for second primary lung cancer
- PDF / 627,999 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 71 Downloads / 176 Views
ORIGINAL ARTICLE
Impact of postoperative complications on outcomes of second surgery for second primary lung cancer Seijiro Sato1 · Masaya Nakamura1,2 · Yuki Shimizu1 · Tatsuya Goto1 · Akihiko Kitahara1,3 · Terumoto Koike1 · Masanori Tsuchida1 Received: 9 January 2020 / Accepted: 5 May 2020 © Springer Nature Singapore Pte Ltd. 2020
Abstract Purpose The best surgical approach for second primary lung cancer remains a subject of debate. The purpose of this study was to review the postoperative complications after second surgery for second primary lung cancer and to investigate the outcomes based on these complications. Methods The clinical data of 105 consecutive patients who underwent pulmonary resection for multiple primary lung cancers between January, 1996 and December, 2017, were reviewed according to the Martini–Melamed criteria. Results After the second surgery, low body mass index (BMI) ( 6 months, respectively [15]. During this period, 1518 patients underwent pulmonary resection for primary lung cancer (Supplementary Table 1), and a total of 106 patients were diagnosed with MPLC according to the Martini–Melamed criteria. After excluding one patient whose initial surgery data were not available, a total of 105 patients were reviewed. The institutional review board approved this study (Niigata University, 2019-0260) and waived the requirement for informed consent because it was a retrospective review. The following parameters were extracted from the medical records: sex, age, smoking history, body mass index (BMI), pulmonary function test results, presence of comorbidities, tumor location (hilum or peripheral), laterality of the second tumor, neoadjuvant therapy, surgical approach, extent of pulmonary resection, histological type, and postoperative complications. The comorbidity score was classified using the Charlson comorbidity index (CCI) [16]. The tumor, node, and metastasis (TNM) stage was unified according to the seventh edition of the TNM classification for lung cancer [17]. The interval between tumors was calculated from the date of resection of the initial tumor to the date of detection of the second primary lung cancer by imaging. Surgery-related complications were graded according to the Clavien-Dindo classification [18, 19]. Complications of Grade ≥ II were included in this analysis.
Categorical variables are presented as numbers and percentages, and continuous variables are presented as means ± the standard deviation. The categorical variables were compared using the Chi-squared test or Fisher’s exact test when there were ≤ 5 observations in a cohort, and Student’s t-test or the Mann–Whitney U test for continuous variables. Using a threshold of P
Data Loading...
