Implications of flavonoids as potential modulators of cancer neovascularity
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REVIEW – CANCER RESEARCH
Implications of flavonoids as potential modulators of cancer neovascularity Alena Liskova1 · Lenka Koklesova1 · Marek Samec1 · Elizabeth Varghese2 · Mariam Abotaleb2 · Samson Mathews Samuel2 · Karel Smejkal3 · Kamil Biringer1 · Martin Petras4 · Dana Blahutova5 · Ondrej Bugos6 · Martin Pec7 · Marian Adamkov8 · Dietrich Büsselberg2 · Rachele Ciccocioppo9 · Mariusz Adamek10 · Luis Rodrigo11 · Martin Caprnda12 · Peter Kruzliak13,14 · Peter Kubatka7 Received: 17 August 2020 / Accepted: 1 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of antiangiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. Methods This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. Results and conclusion Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest. Keywords Cancer · Tumor angiogenesis · Neovascularity · Flavonoids · VEGF · Anti-cancer therapy
* Dietrich Büsselberg dib2015@qatar‑med.cornell.edu
6
Lambda Life JSC., Bratislava, Slovakia
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Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia
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Department of Histology and Embryology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
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Gastroenterology Unit, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Policlinico GB Rossi, University of Verona, Verona, Italy
* Peter Kruzliak [email protected] * Peter Kubatka [email protected] 1
Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
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Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha 24144, Qatar
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Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
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5
Biomedical Center Martin, Jessenius Faculty of Medicine in Martin,
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