Improved spillover correction model to quantify myocardial blood flow by 11 C-acetate PET: comparison with 15 O-H 2 O PE
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ORIGINAL ARTICLE
Improved spillover correction model to quantify myocardial blood flow by 11C-acetate PET: comparison with 15O-H2O PET Yuki Mori • Osamu Manabe • Masanao Naya • Yuuki Tomiyama • Keiichiro Yoshinaga • Keiichi Magota • Noriko Oyama-Manabe • Kenji Hirata • Hiroyuki Tsutsui • Nagara Tamaki • Chietsugu Katoh
Received: 20 February 2014 / Accepted: 2 September 2014 / Published online: 11 September 2014 Ó The Japanese Society of Nuclear Medicine 2014
Abstract Objective 11C-acetate has been applied for evaluation of myocardial oxidative metabolism and can simultaneously estimate myocardial blood flow (MBF). We developed a new method using two-parameter spillover correction to estimate regional MBF (rMBF) with 11C-acetate PET in reference to MBF derived from 15O-H2O PET. The usefulness of our new approach was evaluated compared to the conventional method using one-parameter spillover correction. Methods Sixty-three subjects were examined with 11Cacetate and 15O-H2O dynamic PET at rest. Inflow rate of 11 C-acetate (K1) was compared with MBF derived from 15 O-H2O PET. For the derivation, the relationship between K1 and MBF from 15O-H2O was linked by the Renkin-
Y. Mori C. Katoh Faculty of Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan O. Manabe (&) Y. Tomiyama K. Magota K. Hirata N. Tamaki Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, Hokkaido 0608638, Japan e-mail: [email protected] M. Naya H. Tsutsui Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan K. Yoshinaga Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan N. Oyama-Manabe Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan
Crone model in 20 subjects as a pilot group. One-parameter and two-parameter corrections were applied to suppress the spillover between left ventricular (LV) wall and LV cavity. Validation was set using the other 43 subjects’ data. Finally, rMBFs were calculated using relational expression derived from the pilot-group data. Results The relationship between K1 and MBF derived from 15O-H2O PET was approximated as K1 = [1–0.764 9 exp(-1.001/MBF)] MBF from the pilot data using the two-parameter method. In the validation set, the correlation coefficient between rMBF from 11C-acetate and 15 O-H2O demonstrated a significantly higher relationship with the two-parameter spillover correction method than the one-parameter spillover correction method (r = 0.730, 0.592, respectively, p \ 0.05). Conclusion In 11C-acetate PET study, the new twoparameter spillover correction method dedicated more accurate and robust myocardial blood flow than the conventional one-parameter method. Keywords 11C-acetate 15O-H2O PET Regional myocardial blood flow Spillover correction
Introduction 11
C-acetate is a known PET tracer that is taken up by the heart, rapidly converted to acetyl CoA,
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