In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocataly
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ORIGINAL PAPER
In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocatalytic biosensor and its application for the determination of glucose in human serum Shuisheng Hu 1,2 & Yuxia Lin 1 & Jing Teng 3 & Wing-Leung Wong 2 & Bin Qiu 1 Received: 18 July 2020 / Accepted: 4 November 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract A new electrocatalytic biosensor (MOF-74(Cu) NS-CC) based on the in situ deposition of MOF-74(Cu) nanosheet on carbon cloth via a bottom-up synthetic approach in a glass tube was developed. The electrocatalytic activity of the deposited MOF-74(Cu) NS was demonstrated in the oxidation of glucose to gluconate under alkaline conditions. The results revealed that the proposed method of in situ formation of MOF-74(Cu) NS onto a carbon cloth surface in a multi-layer solution is capable to generate a stable MOF74(Cu) NS-CC electrode with excellent sensing performance. When the as-synthesized MOF-74(Cu) NS-CC was applied directly as the working electrode for glucose sensing, it showed much higher conductivity and redox activity than MOF-74(Cu) NS-GCE. With the potential applied at 0.55 V (vs. Ag/AgCl), this new electrocatalytic biosensor exhibits an excellent linear relationship between current density and concentration of glucose. Moreover, a wide linear range of detection (1.0 to 1000 μM) was observed. The limit of detection was found to be 0.41 μM (S/N = 3). The response sensitivity is 3.35 mA mM−1 cm−2 when the concentration of glucose is in the range 1–100 μM and 3.81 mA mM−1 cm−2 for the 100–1000 μM concentration range. This study provides a low-cost, easy to prepare, and reproducible methodology for the synthesis of highly redox-active nanomaterials based on the in situ formation of two-dimensional MOF-74(Cu) NS for the development of new electrocatalytic biosensors.
Keywords MOF-74(Cu) . Two-dimensional metal-organic framework nanosheet . Bottom-up synthesis . In situ deposition . Carbon cloth . Electrochemical catalysis . Electrochemical biosensor . Glucose sensor . Glucose oxidation . Non-enzymatic method Shuisheng Hu and Yuxia Lin contributed equally to this work.
Introduction
* Jing Teng [email protected]
Metal-organic frameworks (MOFs) are multi-functional materials that have great plasticity in nano-engineering to create unique functionality and are widely applied in a broad area of material science [1–4] and sensing [5, 6]. Some recent developments of MOFs have extended their applications in electrocatalysis and electroanalysis because a number of advantages could be achieved by integrating MOFs to develop new materials for these important applications. MOFs are porous crystalline materials and may act as host substrates for the immobilization of catalysts, such as nanoparticles and enzymes [7, 8]. Moreover, MOFs can be used as the sacrificial templates for calcinations into metallic or carbonaceous nanomaterials to produce structurally defined electrocatalysts [9–11]. However, most investiga
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