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In this issue
# Springer-Verlag GmbH Germany, part of Springer Nature 2020
In this issue, several articles about the gastrointestinal tract are published as well as articles about the other sites including the breast, lung, head and neck, female genital tract, and kidneys. A review article is dealing with digital microscopy. Besides conventional light microscopy, digital microscopy has been increasingly becoming an alternative tool for diagnostic pathology, research, and teaching. Digital microscopy offers the possibility of online instead of onsite activities which provides an enormous advantage for a large number of situations including distant learning and studying and facing restrictions of social contacts during a pandemic. In addition, digital microscopy allows the application of artificial intelligence for the assessment of biomarkers. Rodrigues-Fernandes et al. (https://doi.org/ 10.1007/s00428-020-02908-3) systematically analyzed the use of digital microscopy for teaching in medical and dental schools on the basis of eight articles. The students’ perceptions were assessed by a questionnaire which tested among others the easiness of equipment use and the quality of images as well the preference for one method. In half of the studies, the students’ achievements were found similar or better compared with conventional microscopy. The majority of the studies indicated the students’ support of digital microscopy as an appropriate method for learning. Costa-Morreira et al. (https://doi.org/10.1007/s00428-02002824-6) studied the clinical implications of liver biopsy findings in cases of drug-induced liver injury (DILI) in correlation with clinical and biochemical findings. The analytical toxicity profile was more often hepatocellular than cholestatic, whereas the predominant histological patterns were necroinflammation and cholestasis but without a uniform correlation between clinical and biochemical patterns. A group of most implicated drugs were antimicrobials. The authors recommend performing liver biopsy for better insights into the pathomechanisms associated with DILI and if clinical suspicion of DILI persists. Özakinci et al. (https://doi.org/10.1007/s00428-02002832-6) studied the significance of duodenal bulb biopsies in the diagnostic procedure of pediatric and
adult coeliac disease. In particular, in pediatric and focal adult cases, the diagnosis of coeliac disease may have been missed if duodenal bulb biopsy would not have been performed. Therefore, the authors address the importance of taking duodenal biopsies from multiple sites and recommend a careful classification of each biopsy site according to the Marsh scheme for not missing mild lesions. Zhu and Bledsoe (https://doi.org/10.1007/s00428-02002799-4) studied retrospectively the pattern of poorly cohesive and signet ring cell adenocarcinomas of the gastrointestinal tract in frozen sections. They highlighted various histological features of high significance to distinguish tumor cells from inflammatory cells and reactive tissue alterations an
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