In Vitro Release and Degradation Study of Letrozole-Loaded Poly(Lactic- co -Glycolic Acid) Microparticles
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https://doi.org/10.1007/s11837-020-04482-0 2020 The Minerals, Metals & Materials Society
TECHNICAL ARTICLE
In Vitro Release and Degradation Study of Letrozole-Loaded Poly(Lactic-co-Glycolic Acid) Microparticles AKHTAR JAHAN SIDDIQA,1 NILESH KUMAR SHRIVASTAVA,2 M.E. ALI MOHSIN,2 MUSTUFA HAIDER ABIDI ,3,6 MOHAMED ABDEL FATTAH SHARAF,4 and TAUQEER AHMED SHAIKH5 1.—Materials Science Centre, Indian Institute of Technology, Kharagpur, West Bengal 721302, India. 2.—Enhanced Polymer Research Group, School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia. 3.—Advanced Manufacturing Institute, King Saud University, Riyadh 11421, Saudi Arabia. 4.—Industrial Engineering Department, College of Engineering, King Saud University, Riyadh 11421, Saudi Arabia. 5.—Electrical Engineering Department, College of Engineering, King Saud University, Riyadh 11421, Saudi Arabia. 6.—e-mail: [email protected]
This work describes the stability and in vitro release of letrozole (drug)-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles. To control the release capacity of the drug, the microparticles were fabricated with different ratios of biopolymer using solvent evaporation techniques. Further, the drug encapsulation efficiency, physicochemical properties, and morphologies were measured. In vitro release data of the drug were fitted to three theoretical models to evaluate the release kinetics. The highest correlation coefficient was found in Higuchi and Korsmeyer–Peppas that ensured the controlled release of the encapsulated drug from the microparticles. Scanning electron microscopy and Fourier-transform infrared spectroscopy analysis with gradual degradation time up to 80 days revealed the stability of PLGA, and stabilized the drug bioavailability.
INTRODUCTION Nano- or micro-carriers have unique properties such as high carrier capacity, high stability over extended periods of storage, and the hydrophilic/ hydrophobic substances encapsulation ability.1,2 for the last 10 years, nanoparticles (NPs) and microparticles (MPs) have been used as carriers for drug delivery applications. The main purpose of the encapsulation of a therapeutic agent into the carrier is to deliver the drug at a controlled and/or sustained release rate over a prolonged period of time, e.g., several weeks or years,3,4 reduce the dosing frequency of drug administration, and stabilize the drug bioavailability.5 Consequently, natural and synthetic biodegradable polymers have been widely used as drug carriers in NPs and MPs formulations. Synthetic polymers such as poly(amino acids), poly(amides), poly(esters), poly(acrylamide), poly(lactic acid),
(Received November 3, 2019; accepted October 27, 2020)
poly(glycolic acid), poly(caprolactone), poly(lacticco-glycolic acid) (PLGA), poly(hydroxy valerate), and poly(hydroxybutyrate) have been used as drug carriers.6–8 The particles obtained using these polymers can be degraded via enzymatically or nonenzymatically process in vivo that produces nontoxic products and removed
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