In Vivo Reprogramming in Regenerative Medicine
There have been significant improvements in the development of cell based therapies; however, current treatment strategies still suffer from some problems: the need for long in vitro culture conditions, inefficient delivery of cells by scaffolds and low i
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Açelya Yilmazer Editor
In Vivo Reprogramming in Regenerative Medicine
Stem Cell Biology and Regenerative Medicine
Series Editor Kursad Turksen, Ph.D.
More information about this series at http://www.springer.com/series/7896
Açelya Yilmazer Editor
In Vivo Reprogramming in Regenerative Medicine
Editor Açelya Yilmazer Biomedical Engineering Department Ankara University Tandogan, Ankara, Turkey Stem Cell Institute Ankara University Balgat, Ankara, Turkey
ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-319-65719-6 ISBN 978-3-319-65720-2 (eBook) DOI 10.1007/978-3-319-65720-2 Library of Congress Control Number: 2017952394 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To my parents, Reyhan and Ali Ulvi, and the love of my life, Süleyman, and to Zeki Yaman, you all made it worthwhile.
Preface
This new volume, as a part of Springer’s Stem Cells in Regenerative Medicine series, is dedicated to review the current progress on different approaches of in vivo reprogramming technology. Leaders in the field discuss how in vivo reprogramming can be used for tissue repair and regeneration in different organs, including the pancreas (Chap. 2), liver (Chap. 3), and heart (Chap. 4). Recent studies on in vivo cell reprogramming toward pluripotency are also reviewed; examples are given in order to show its potential in regenerative medicine (Chaps. 5 and 6). In each chapter, the regenerative potential of different in vivo reprogramming approaches is discussed in detail. Examples from various animal models are given, and the regenerative potential
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