Increase of magnetic hyperthermia efficiency due to optimal size of particles: theoretical and experimental results
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RESEARCH PAPER
Increase of magnetic hyperthermia efficiency due to optimal size of particles: theoretical and experimental results L. H. Nguyen & V. T. K. Oanh & P. H. Nam & D. H. Doan & N. X. Truong & N. X. Ca & P. T. Phong & L. V. Hong & T. D. Lam Received: 29 April 2020 / Accepted: 11 August 2020 # Springer Nature B.V. 2020
Abstract In this study, the Fe3O4 nanoparticles with particle size from 5 to 20 nm were synthesized using the thermal decomposition method. Magnetic hyperthermia measurements on these nanoparticles show moderate values of the specific absorption rates (SAR) in applied AC magnetic fields of amplitude 200 Oe and frequencies of 450 kHz. The highest value of SAR is 123.31 W/g for 20 nm Fe3O4 MNPs. The theoretical results within the framework of the linear response theory were used for L. H. Nguyen : P. T. Phong Laboratory of Magnetism and Magnetic Materials, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam e-mail: [email protected] L. H. Nguyen : P. T. Phong Faculty of Applied Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam V. T. K. Oanh (*) : P. H. Nam : D. H. Doan : N. X. Truong : L. V. Hong Institute of Materials Science, Vietnam Academy of Science and Technology, 18- Hoang Quoc Viet Road, Hanoi, Vietnam e-mail: [email protected] V. T. K. Oanh Graduate University of Science and Technology, 18- Hoang Quoc Viet Street, Cau Giay District, Hanoi, Vietnam N. X. Ca Department of Physics and Technology, TNU - University of Science, Thai Nguyen City, Vietnam T. D. Lam Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Hanoi, Vietnam
comparing with experimental ones. The value of SAR obtained through magnetothermal measurements is found to be in excellent agreement with that obtained using the linear response theory. These results open the path to a more accurate prediction for synthesis of magnetic fluids for applications in magnetic hyperthermia. Keywords Magnetic induction heating . Nanoparticles . Fe3O4 . Thermal decomposition . Particle size
Introduction Magnetic nanoparticles (MNPs) have gained great interest because of their potential biomedical applications such as drug delivery and hyperthermia (Lu et al., 2007; Ha et al., 2019; Le et al., 2018; Le ThiThu Huong et al., 2016). Especially, MNPs have become a nanosized heating source, which is used as a thermal seed in “killing” cancer cells in hyperthermia by magnetic induction heating (MIH) effect (Lu et al., 2007). In biomedical applications, the concentrations of MNPs must be controlled as low as possible to ensure body human (Obaidat & Haik, 2015). Therefore, the important requirement is optimizing the physical characterizations of MNPs to seek for the proper particle material of high induction heating performance. In addition, MNPs must meet other requirements such as being stable, weakly agglomerated, and small in size (Mehdaoui et al., 2011). Large-sized magnetic nanoparticles with high coercivity are not recommenda
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