Increases in youth suicide deaths after FDA antidepressant warnings
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Increases in youth suicide deaths after FDA antidepressant warnings Youth suicide deaths increased substantially following US FDA antidepressant boxed warnings regarding suicidality for adolescents and young adults and the accompanying declines in depression care. This is the main finding of a US study that used an interrupted times series design to examine changes in population suicide death rates among adolescents (aged 10–19 years) and young adults (aged 20–24 years) over a 28-year period (1990–2017), comparing suicide death rates before the FDA warnings with those after the warnings. During the 13-year period before the warnings (1990–2002), there was a significant downward trend in suicide deaths among adolescents and young adults. After the 2005 FDA warnings and accompanying declines in depression care, this downward trend reversed. There was an immediate increase of 0.49 suicide deaths per 100 000 adolescents (95% CI: 0.12, 0.86) and a trend increase of 0.03 suicide deaths per 100 000 adolescents per year (95% CI: 0.026, 0.031). Similarly, there was an immediate increase of 2.07 suicide deaths per 100 000 young adults (95% CI: 1.04, 3.10) and a trend increase of 0.05 suicide deaths per 100 000 young adults per year (95% CI: 0.04, 0.06). These figures may reflect 2365 excess suicide deaths among adolescents and 3593 among young adults from 2005 through 2010 in the US, based on the annual size of these populations (averaged 43 million and 21 million, respectively). Lu CY, et al. Increases in Suicide Deaths Among Adolescents and Young Adults Following US Food and Drug Administration Antidepressant Boxed Warnings and Declines 803508763 in Depression Care. Psychiatric Research and Clinical Practice : 7 Oct 2020. Available from: URL: https://doi.org/10.1176/appi.prcp.20200012
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Reactions 17 Oct 2020 No. 1826
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