Indian Traditional medicinal plants as a source of potent Anti-diabetic agents: A Review
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REVIEW ARTICLE
Indian Traditional medicinal plants as a source of potent Anti-diabetic agents: A Review Vishakha Parab Gaonkar 1 & Kirankumar Hullatti 1 Received: 27 May 2020 / Accepted: 3 September 2020 # Springer Nature Switzerland AG 2020
Abstract Objective The present review aims to provide an overview of traditional medicinal plants known to be of anti-diabetic potential. Methods A literature search was conducted using the scientific databases including PubMed, EMBASE and google scholar and a total of fifty herbs have been described and their possible mechanism of anti-diabetic action has been mentioned. Among them, in-depth discussion on five most potent anti-diabetic herbs has been provided with respect to their mechanism of action, in-vivo studies and clinical efficacies. Results The present review has highlighted the usefulness of the herbal source for the treatment and management of diabetes mellitus. With the help of previous literature published on In-vivo animal studies and human clinical studies; the effectiveness of Gymnema sylvestre, Momordica charantia, Trigonella foenum graecum, Tinospora cordifolia and Curcuma longa in the treatment and management of Diabetes has been proved. Conclusion Based on this review it can be concluded that herbs can serve as more efficient, safer, and cost-effective adjuvant therapy in the management and treatment of diabetes. Further investigations mainly focusing on the isolation of phytocompounds from these herbs can lead to the discovery of newer antidiabetic agents. Keywords Anti-diabetic . Diabetes mellitus . Herbs . Hyperglycaemia . Medicinal plants . Phytocompounds
Introduction Diabetes mellitus is one of the most prevalent diseases found in all parts of the world and is becoming a serious threat to mankind’s health [1]. It is a complex heterogeneous group of metabolic disorders including hyperglycemia and is associated with the imbalance in carbohydrate, protein, and lipid metabolism [2]. According to WHO, “Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. Such a deficiency results in increased concentrations of glucose in the blood, which in turn damage many of the body’s systems, in particular the blood vessels and nerves” [3]. According to the recent data by International Diabetes Federation (IDF) Atlas claims that
* Kirankumar Hullatti [email protected] 1
Department of Pharmacognosy and Phytochemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, India
around 463 million adults are currently living with diabetes and estimates that there will be 578 million adults with diabetes by 2030, and 700 million by 2045 [4]. The management of diabetes mellitus is considered a global problem. In current allopathic therapy the oral hypoglycaemic agents and insulin, are subsequently used to control the diabetic conditions, however, complications associated with them, limited tolerabil
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