Infantile neuroblastoma of the urinary bladder detected by hematuria
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CASE REPORT
Infantile neuroblastoma of the urinary bladder detected by hematuria Shin-ichiro Kojima • Minoru Yagi • Kimio Asagiri • Suguru Fukahori • Yoshiaki Tanaka Shinji Ishii • Nobuyuki Saikusa • Yoshinori Koga • Motomu Yoshida • Daisuke Masui • Naoko Komatsuzaki • Shin-ichiro Nakagawa • Shuichi Ozono • Ken Tanikawa
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Accepted: 20 March 2013 / Published online: 31 March 2013 Ó Springer-Verlag Berlin Heidelberg 2013
Abstract Malignant tumors of the urinary bladder in infants are extremely rare. Rhabdomyosarcoma is the most likely tumor in this site, whereas neuroblastoma of the urinary bladder is exceedingly uncommon and is not listed as a differential diagnosis for tumors of this site. We present a case of neuroblastoma arising from the dome of the bladder wall, detected by hematuria. Only six cases of neuroblastoma originating from the bladder, including the present case have been reported. Of the cases, five arose from the dome of the bladder wall. In this report, the differential diagnosis of bladder tumors in children is discussed. A diagnosis of neuroblastoma should be taken into consideration, especially in the case of tumors arising from the dome of the bladder wall despite an uncommon location. Keywords Hematuria
Neuroblastoma Urinary bladder Infant
S. Kojima M. Yagi K. Asagiri S. Fukahori (&) Y. Tanaka S. Ishii N. Saikusa Y. Koga M. Yoshida D. Masui N. Komatsuzaki Department of Pediatric Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan e-mail: [email protected] S. Kojima e-mail: [email protected] S. Nakagawa S. Ozono Department of Pediatrics, Kurume University School of Medicine, Fukuoka 830-0011, Japan K. Tanikawa Department of Pathology, Kurume University School of Medicine, Fukuoka 830-0011, Japan
Introduction Malignant tumors of the urinary bladder in infants are extremely rare. Most of the patients suffering such tumors generally present non-specific urinary symptoms or a palpable pelvic mass at diagnosis. Rhabdomyosarcoma has been known as the most likely tumor in this site, which frequently affects the genitourinary structures of the pelvis in both males and females [1]. Several other benign or malignant tumors of the urinary bladder have so far been reported, such as neurofibroma, angioma, pheochromocytoma, leiomyosarcoma and transitional cell carcinoma [2, 3]. The most common primary site of neuroblastoma is the adrenal gland (40 %), following the sympathetic ganglia of the abdomen (25 %), thorax (15 %), neck (5 %) and pelvis (5 %) [4]. Other rare primary sites of neuroblastoma so far reported are the orbit, lung and genitourinary tract [4]. In particular, neuroblastoma located on the urinary bladder region is extremely unusual. However, it seems to be a favorable prognostic group [5–7]. We herein report a case of neuroblastoma arising from the dome of the bladder wall and discuss a review of literatures.
Case report A 4-month-old male infant, with no relevant familial history of dis
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