Infertility treatment outcome in sub groups of obese population
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Infertility treatment outcome in sub groups of obese population Khalid A Awartani*1,2, Samar Nahas1, Saad H Al Hassan1, Mashael A Al Deery1 and Serdar Coskun3 Address: 1Reproductive Medicine, Department of Obstetrics & Gynecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, 2Alfaisal Collage of Medicine, Alfaisal University, Riyadh, Saudi Arabia and 3Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia Email: Khalid A Awartani* - [email protected]; Samar Nahas - [email protected]; Saad H Al Hassan - [email protected]; Mashael A Al Deery - [email protected]; Serdar Coskun - [email protected] * Corresponding author
Published: 27 May 2009 Reproductive Biology and Endocrinology 2009, 7:52
doi:10.1186/1477-7827-7-52
Received: 27 December 2008 Accepted: 27 May 2009
This article is available from: http://www.rbej.com/content/7/1/52 © 2009 Awartani et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Obesity is a common disorder with a negative impact on IVF treatment outcome. It is not clear whether morbidly obese women (BMI >= 35 kg/m2) respond to treatment differently as compared to obese women (BMI = 30–34.9 kg/m2) in IVF. Our aim was to compare the outcome of IVF or ICSI treatments in obese patients to that in morbidly obese patients. Methods: This retrospective cohort study was conducted in a tertiary care centre. Patients inclusion criteria were as follows; BMI ≥ 30, age 20–40 years old, first cycle IVF/ICSI treatment with primary infertility and long follicular pituitary down regulation protocol. Results: A total of 406 obese patients (group A) and 141 morbidly obese patients (group B) satisfied the inclusion criteria. Average BMI was 32.1 ± 1.38 kg/m2 for group A versus 37.7 ± 2.99 kg/m2 for group B. Patient age, cause of infertility, duration of stimulation, fertilization rate, and number of transferred embryos were similar in both groups. Compared to group A, group B had fewer medium size and mature follicles (14 vs. 16), fewer oocytes collected (7 vs. 9) and required higher doses of HMG (46.2 vs. 38.5 amps). There was also a higher cancellation rate in group B (28.3% vs. 19%) and lower clinical pregnancy rate per started cycle (19.9% vs. 28.6%). Conclusion: In a homogenous infertile and obese patient population stratified according to their BMI, morbid obesity is associated with unfavorable IVF/ICSI cycle outcome as evidenced by lower pregnancy rates. It is recommended that morbidly obese patients undergo appropriate counseling before the initiation of this expensive and invasive therapy.
Background Obesity is considered to be the greatest nutritional problem in the industrialized wo
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