Inflammatory biomarkers and dynamics of neutrophil-to-lymphocyte ratio in anaplastic thyroid carcinoma
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ORIGINAL ARTICLE
Inflammatory biomarkers and dynamics of neutrophil-to-lymphocyte ratio in anaplastic thyroid carcinoma Haruhiko Yamazaki1 Kiminori Sugino1 Kenichi Matsuzu1 Chie Masaki1 Junko Akaishi1 Kiyomi Hames1 Chisato Tomoda1 Akifumi Suzuki1 Takashi Uruno1 Keiko Ohkuwa1 Wataru Kitagawa1 Mitsuji Nagahama1 Munetaka Masuda2 Koichi Ito1 ●
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Received: 25 February 2020 / Accepted: 8 April 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Studies have shown that inflammatory biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-tolymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), are associated with prognosis or treatment efficacy in various cancers. The present study investigated the association between the inflammatory biomarkers and dynamics of NLR, and prognosis or disease progression in anaplastic thyroid carcinoma (ATC). Methods This study included 55 patients with ATC who had available complete blood count (CBC) data. Overall survival based on inflammatory biomarker value, and the dynamics of NLR among patients with ATC were investigated. Change in NLR was obtained by subtracting the baseline value from the max value obtained during follow-up period, and we subclassified 51 ATC patients who had follow-up CBC data into the increased group (change of NLR > 5.5) and nonincreased group (change of NLR ≤ 5.5). Results There were no significant differences in OS according to baseline NLR, PLR, and LMR values. Among the 51 patients with ATC who had follow-up CBC data, the median OS was 7.7 [95% confidence interval (CI): 5.2–12.1] months in the increased group (n = 27), versus 23.5 [95% CI: 13.9–not available] months in the non-increased (n = 24) group (p < 0.001). Conclusions The present study found no association between baseline inflammatory biomarkers and OS among patients with ATC. However, ATC patients whose NLR increased compared with individual baseline during follow-up period had worse prognosis than non-increased patients. Keywords Carcinoma Inflammation Oncology Thyroid ●
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Introduction Tumor microenvironment and inflammatory response play an important role in cancer development and progression and may be associated with systemic inflammation, which also affects immune surveillance and response to therapy [1]. Elevated C-reactive protein levels or white blood cell (WBC) counts are measurable blood parameters that have been
* Haruhiko Yamazaki [email protected] 1
Department of Surgery, Ito Hospital, 4-3-6, Jingumae, Shibuya-ku, Tokyo 150-8308, Japan
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Department of Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawaku, Yokohama City, Kanagawa, Japan
known to reflect systemic inflammatory response [2]. The neutrophil-to-lymphocyte ratio (NLR) functions as an accurate and reliable index of systemic inflammation and, thus, serves as a systemic marker of inflammation [3]. Recently, reports have shown that the NLR is associated with prognosis or treatment effi
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