Inflammatory Risk Factors for Early Recurrence of Non-Small Cell Lung Cancer Within One Year Following Curative Resectio
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ORIGINAL SCIENTIFIC REPORT
Inflammatory Risk Factors for Early Recurrence of Non-Small Cell Lung Cancer Within One Year Following Curative Resection Satoru Kobayashi1 • Yoko Karube1 • Yuji Matsumura2 • Morimichi Nishihira1 Takashi Inoue1 • Osamu Araki1 • Sumiko Maeda1 • Masayuki Chida1
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Ó Socie´te´ Internationale de Chirurgie 2020
Abstract Background Several inflammation-based scoring systems and nutritional indicators have been shown to have relevance to survival of patients with non-small cell lung cancer (NSCLC).The present study examined preoperative and pathological factors in patients who underwent curative resection for non-small cell lung cancer, with the aim to elucidate risk factors for early recurrence within 1 year of surgery. Methods Patients with NSCLC who underwent surgery from January 2009 to December 2014 were retrospectively investigated. Routine laboratory measurements including carcinoembryonic antigen were performed before surgery, and pathological information was collected after surgery. Patients with recurrence within 1 year after surgery were considered as early recurrence group (ERG), those with recurrence after 1 year were as late recurrence group (LRG), and those without recurrence were as no recurrence group (NRG). Results Multivariate analysis between ERG and LRG revealed Glasgow prognostic score (GPS) and CRP-to-albumin ratio (CAR) as independent risk factors for early recurrence. Multivariate analysis between ERG and LRG ? NRG confirmed CAR, vascular invasion, and pathological stage as risk factors for early recurrence. Conclusion These findings indicated that CAR and GPS were confirmed to be risk factors for early recurrence, in addition to pathological factors.
Introduction Lung cancer is a major contributor to cancer-associated deaths worldwide [1]. In Japan, the lung cancer mortality rate has shown consistent annual increases since it became ranked as the leading cause of cancer death in the latter half of the 1990s [2]. According to a scientific investigation conducted by the Japanese Association for Thoracic & Satoru Kobayashi [email protected] 1
Department of General Thoracic Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0294, Japan
2
Department of General Thoracic Surgery, Dokkyo Saitama Medical Center, Koshigaya, Saitama, Japan
Surgery in 2010, the number of cases that underwent resection was 11,663 in 2004 and the 5-year survival rate was 69.6% [3]. A variety of factors are involved in patient prognosis and recurrence of non-small cell lung cancer following a curative resection procedure. In addition to those indicating cancer progression, including tumor size, presence of lymph-node metastasis, vascular invasion, and pleural infiltration, patient background factors like comorbidity of respiratory diseases such as interstitial pneumonia and emphysema, as well as nutritional status and inflammation status, are important [4, 5]. It is known that inflammation develops in association with cancer and is related to tumor enlargement and
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