Influence of bowel habits on gut-derived toxins in peritoneal dialysis patients

  • PDF / 750,189 Bytes
  • 9 Pages / 595.276 x 790.866 pts Page_size
  • 64 Downloads / 185 Views

DOWNLOAD

REPORT


ORIGINAL ARTICLE

Influence of bowel habits on gut‑derived toxins in peritoneal dialysis patients Natalia Barros Ferreira Pereira1   · Christiane Ishikawa Ramos2   · Laila Santos de Andrade1   · Renata Rodrigues Teixeira1   · Lia Sumie Nakao3   · Silvia Daniéle Rodrigues3 · Jordana Dinorá de Lima4 · Maria Aparecida Dalboni5 · Lilian Cuppari1,2,6  Received: 7 April 2020 / Accepted: 25 July 2020 © Italian Society of Nephrology 2020

Abstract Background  Gut-derived uremic toxins have been associated with adverse outcomes in chronic kidney disease (CKD). Alterations in bowel habits, including constipation, seem to play an additional role in uremic toxicity. The aim of this study is to investigate the association of bowel habits with gut-derived uremic toxins and intestinal permeability in patients on automated peritoneal dialysis (APD). Methods  This cross-sectional study enrolled 58 APD patients (age 52.5 ± 15.1 years; dialysis vintage 14.1 (6.0–36.5) months). Constipation was defined according to the Rome IV criteria. Bowel habits were assessed by the Bristol Stool Scale (BSS