Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study
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RESEARCH ARTICLE
Open Access
Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study Douglas S Kalman1, Samantha Feldman1, Andrew R Scheinberg1, Diane R Krieger1 and Richard J Bloomer2*
Abstract Background: Methylsulfonylmethane (MSM) has been reported to provide anti-inflammatory and antioxidant effects in both animal and man. Strenuous resistance exercise has the potential to induce both inflammation and oxidative stress. Using a pilot (proof of concept) study design, we determined the influence of MSM on markers of exercise recovery and performance in healthy men. Methods: Eight, healthy men (27.1 ± 6.9 yrs old) who were considered to be moderately exercise-trained (exercising 0.05). Conclusion: MSM, especially when provided at 3.0 grams per day, may favorably influence selected markers of exercise recovery. More work is needed to extend these findings, in particular using a larger sample of subjects and the inclusion of additional markers of exercise recovery and performance. Keywords: Methylsulfonylmethane, Exercise, Oxidative stress, Performance
* Correspondence: [email protected] 2 Department of Health and Sport Sciences, The University of Memphis, Cardiorespiratory/Metabolic Laboratory, 106 Roane Fieldhouse, Memphis TN 38152, USA Full list of author information is available at the end of the article © 2012 Kalman et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Kalman et al. Journal of the International Society of Sports Nutrition 2012, 9:46 http://www.jissn.com/content/9/1/46
Background Methylsulfonylmethane (MSM) is a naturally occurring nutrient composed of sulfur, oxygen and methyl groups [1]. In the presence of ozone and high-energy ultraviolet light, MSM (along with dimethyl sulfoxide [DMSO]) is formed from dimethyl sulfide, taken up into atmosphere, returned to the earth in rainfall, and taken into the root systems of plants. As such, MSM can be found in small quantities in a variety of foods [2], such as milk, fruits and vegetables (e.g., tomatoes, corn), coffee, and tea. While multiple health-related benefits are attributed to sulfur in general [3], and to MSM specifically—ranging from improved physical function [4] to a potential reduction in certain cancer risk [5], the proposed mechanisms of action for MSM appear related to both anti-inflammatory [6] and anti-oxidative activity [7]. MSM may inhibit the translocation of the p65 subunit of nuclear factor (NF)-kß to the nucleus [6], thus minimizing downstream events associated with local and systemic inflammation. Indeed, supplementation with MSM may minimize the expression of pro-inflammatory cytokines [8]. MSM has been reported to increase antioxidant defense (glutathione) [9], as well as decrease the actual production of re
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