Influence of Single and Multi Dose Treatment of Glipizide on Pharmacokinetics and Pharmacodynamics of Irbesartan in Norm
- PDF / 629,771 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 104 Downloads / 146 Views
ORIGINAL ARTICLE
Influence of Single and Multi Dose Treatment of Glipizide on Pharmacokinetics and Pharmacodynamics of Irbesartan in Normal and Hypertensive Rats Adepu Anusha1 • Dudhipala Narendar2 • Boini Krishna Murthy3 Puchchakayala Goverdhan1
•
Received: 19 January 2017 / Accepted: 20 March 2017 Ó Springer International Publishing Switzerland 2017
Abstract Purpose The present study was carried out to investigate the pharmacokinetic and pharmacodynamic drug interaction of irbesartan with glipizide after single and multi dose treatment in normal and hypertensive rat models to evaluate the safety and effectiveness of the combination. Methods The study was conducted on normal and 10% fructose solution induced hypertensive rats. Irbesartan and glipizide were administered orally for 7 days and on 8th day blood samples were collected for 12 h at regular time intervals from irbesartan alone and in combination with glipizide treated groups. The blood samples were analyzed for various pharmacokinetic and pharmacodynamic parameters. Results Irbesartan caused marked reduction in blood pressure in hypertensive rats. The combination of irbesartan and glipizide in hypertensive rats produce significant change in blood pressure (pharmacodynamic) and also significance in pharmacokinetic parameters of irbesartan with glipizide in single dose and multiple doses. & Puchchakayala Goverdhan [email protected] Dudhipala Narendar [email protected] 1
Laboratory of Pharmacokinetics and Toxicokinetics, Department of Pharmacology, Vaagdevi College of Pharmacy, Kakatiya University, Warangal, Telangana 506001, India
2
Department of Pharmaceutics, Vaagdevi Institute of Pharmaceutical Sciences, Warangal, Telangana 506005, India
3
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 3455, Houston, TX 77204, USA
Conclusion The results of present study demonstrated that the synergistic activity of irbesartan with glipizide was observed. Keywords Irbesartan Glipizide Pharmacokinetic Pharmacodynamic Antihypertensive activity
1 Introduction In many chronic ailments, the multi drug therapy may be advocated to mitigate the severity or to avoid the development of possible resistance. There is a possibility of occurrence of drug-drug interactions when multiple drugs are administered simultaneously. These drug interactions can be explained by alteration in the pharmacokinetic parameters including inhibition or induction of metabolic enzymes or by alterations in pharmacodynamic properties of one or both the drugs. Many of the drug interactions occur due to induction or inhibition of hepatic cytochrome P450 enzymes [2, 16]. Hypertension, which coexists with diabetes mellitus is not only an indicator of increased risk of mortality but also a contributory factor to the development of diabetic complications [6]. To treat the coexisting disease, multidrug therapy is inevitable and there is a possibility for a drug interaction to occur when drugs are concomitantly used. Hypertensive patients a
Data Loading...
