Influenza Vaccines for the Future
The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made
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Series Editors Axel Schmidt, University Witten/Herdecke, Faculty of Medicine, Alfred-Herrhausen-Str. 50, 58448 Witten, Germany Olaf Weber, Rheinische Friedrich-Wilhelms-University, Institute of Molecular Medicine, and Experimental Immunology, Sigmund-Freud-Str. 25, 53105 Bonn, Germany Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Charite´platz 1, Campus Charite´ Mitte, D-10117 Berlin, Germany Advisory Board Manfred H. Wolff, University Witten/Herdecke, Faculty of Biosciences, Stockumer Str. 10, 58448 Witten, Germany
For further volumes: http://www.springer.com/series/5444
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Rino Rappuoli
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Giuseppe Del Giudice
Editors
Influenza Vaccines for the Future Second Edition
Editors Dr. Rino Rappuoli Novartis Vaccines & Diagnostics S.r.l. Via Fiorentina 1 53100 Siena Italy
Dr. Giuseppe Del Giudice Novartis Vaccines & Diagnostics S.r.l. Via Fiorentina 1 53100 Siena Italy
ISBN 978-3-0346-0278-5 e-ISBN 978-3-0346-0279-2 DOI 10.1007/978-3-0346-0279-2 Library of Congress Control Number: 2010938614 # Springer Basel AG 2011 Springer Basel AG is part of Springer Science þ Business Media (www.springer.com) This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. Cover illustration: Fig. 2 from E. C. Settembre, P. R. Dormitzer, R. Rappuoli, H1N1: Can a pandemic cycle be broken? Sci. Transl. Med. 2, 24ps14 (2010). Image: Adapted by C. Bickel/Science Translational Medicine. Reprinted with permission from AAAS. Cover design: deblik, Berlin Printed on acid-free paper
Preface
The pandemic caused by the 2009 A/H1N1 influenza virus has changed the manner in which the world will respond to pandemics in the future and will have an important place in history. Why is a relatively mild pandemic so important that it will leave a mark on history? The fact is that this event has represented a test of the global pandemic preparedness and has highlighted weaknesses and strengths of the health protection system worldwide. The best strategy to protect mankind against future pandemics is by vaccination. Thanks to the H5N1 avian influenza, during the past 10 years our ability to control a pandemic has improved considerably. Nevertheless, the 2009 A/H1N1 influenza pandemic has demonstrated the many weaknesses of the current pandemic preparedness plans. These weaknesses would have been fatal had this pandemic resulted in the global spread of a more lethal influenza strain. It can be said that this pandemic has provided a unique opportunity, a “fire drill”, to identify the deficiencies that must be urgently addressed to develop a better and more efficient plan for the next pandemics of the twenty-first century. This second edition of “Influenza Vaccines of the Future” intends to provide the grounds for developing such pl
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