Vaccines

The immune system is the only organ system in the body besides the central nervous systems endowed with memory. Both types of memories are specific and long-lasting, sometimes life long. This memory capacity of the immune system provides the basis for the

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Experimental Pharmacology Volume 133 Editorial Board G.V.R.Born,London P. Cuatrecasas, Ann Arbor, MI D. Ganten, Berlin H. Herken, Berlin K. Starke, Freiburg i. Br. P. Taylor, La Jolla, CA

Springer

Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Singapore Tokyo

Vaccines Contributors T. Bergstrom, M. Corbel, P. Corran, J.1. Donnelly, L. Hellman, I. Hellstrom, K.E. Hellstrom, S.L. Hoffman, J. Holmgren, R. Janssen, D.C. Kaslow, S.H.E. Kaufmann, S. Kumar, C. Laferriere, P.-H. Lambert, M.A. Liu, P. Minor, E. Norrby, M. Pizza, J.T. Poolman, R. Rappuoli, J. Reimann, E.G. Sandstrom, G.c. Schild, F. Schodel, A.M. Schultz, C.-A. Siegrist, A.1. Slavin, V.c. Stevens, A.-M. Svennerholm, B. Svennerholm, S.B. Svenson, J. Thole, J.B. Ulmer, A. Vahlne, H.L. Weiner, D. Young

Editors

P. Perlmann and H. Wigzell

Springer

Professor PETER PERLMANN

The Wenner-Gren Institute Department of Immunology Stockholm University The Arrhenius Laboratories F5 S-106 91 Stockholm SWEDEN Professor HANS WIGZELL

MTC, Karolinska Institute S-171 77 Stockholm SWEDEN With 16 Figures and 20 Tables ISBN 978 -3 - 642 - 64196 -1 Springer-Verlag Berlin Heidelberg New York Library of Congress Cataloging-in-Publication Data

Vaccines 1contributors, T. Bergstrom ... let al.]; editors, P. Perlmann and H. Wigzell. p. cm. - (Handbook of experimental pharmacology; v. 133) Includes bibliographical references and index. ISBN978 - 3 - 642 - 6419 6 -l(hardcover: alk. paper) 1. Vaccines. I. Bergstrom, T. (Tomas) I!. Perl mann, Peter. III. Wigzell, Hans, 1938- . IV. Series. [DNLM: 1. Vaccines-therapeutic use. 2. Vaccines-pharmacology. 3. Immune System-physiopathology. WIHA51L v. 133 1999] QP905.H3 vol. 133 [RM281] 651'.1 s-dc21 [651'.372] DNLMIDLC for Library of Congress 98-42189 CIP This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9,1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. ISBN-13: 978 - 3 - 642 - 64196-1 DOI:l0.l007!978-3-642-59955-2

© Springer-Verlag Berlin Heidelberg 1999

e-ISBN-13:978-3-642-59955-2

Softcover reprint of the hardcover 15t edition 1999 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover