Inhibitors of Cell Growth
The containment of cell growth is at the core of the homeostatic regulation of metazoans, and considerable progress has been made in the understanding of how this is achieved. Most knowledge comes from the isolation of molecu les with positive and negati
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Springer Berlin Heidelberg New York Barcelona Budapest Hong Kong London Milan Paris Singapore Tokyo
Alvaro Macieira-Coelho (Ed.)
Inhibitors of Cell Growth
With 22 Figures
,
Springer
Professor Dr. A. Macieira-Coelho INSERM 73 bis, Rue du Man~chal Foch 78000 Versailles France
ISBN 978-3-642-72151-9
Library of Congress Cataloging-in-Publication Data Inhibitors of cell growth / Alvaro Macieira-Coelho (ed.) . p. cm. -- (Progress in molecular and subcellular biology; 20) Includes bibliographical references and index. ISBN 978-3-642-72151-9 ISBN 978-3-642-72149-6 (eBook) DOI 10.1007/978-3-642-72149-6 I. Cells--Growth--Regulation. 2. Cancer cells--Growth-Regulation. 3. Growth factors. 4. Interferon. 5. Oncogenes. 6. Antioncogenes. I. Macieira-Coelho, Alvaro, 1932- II. Series. QH604.I53 1998 571.8'49--dc21 This work is subject to copyright. All rights are reserved, wether the whole or part of the material is concerned, specifically the rights of translation, reprinting reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data Banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9,1965, in its current version, and permissions for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer- Verlag Berlin Heidelberg 1998 sottcover reprint of the hardcover 1st edition 1998
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Preface
The containment of cell growth is at the core of the homeostatic regulation of metazoans, and considerable progress has been made in the understanding of how this is achieved. Most knowledge comes from the isolation of molecules with positive and negative regulatory effects on cell proliferation, and most emphasis so far has been on these molecules. Some of these molecules are already available for therapeutic purposes, and others look promising in this respect. This volume gives examples of such approaches. The understanding of the control of cell growth is also fundamental to grasp phylogenic and ontogenic development. Why organisms have developed increasingly sophisticated mechanisms that control their size and that of their organs, how different cells originate, some destined for renewal and repair, others for specialized functions in a postmitotic state or evolving through division, others like the germinal cells waiting for the signal to start another organism. There is one mechanism of growth containment, however, about which we know very little. It concerns the structural
