Inhibitors of p38 Mitogen-Activated Protein Kinase
- PDF / 364,861 Bytes
- 17 Pages / 612.28 x 790.87 pts Page_size
- 119 Downloads / 208 Views
Biodrugs 2003; 17 (2): 113-129 1173-8804/03/0002-0113/$30.00/0 © Adis Data Information BV 2003. All rights reserved.
Inhibitors of p38 Mitogen-Activated Protein Kinase Potential as Anti-inflammatory Agents in Asthma? Robert Newton1,2 and Neil Holden1 1 Department of Biological Sciences, University of Warwick, Coventry, UK 2 Thoracic Medicine, National Heart & Lung Institute, Imperial College Faculty of Medicine, London, UK
Contents Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1. Asthma and Current Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. p38 Mitogen-Activated Protein Kinase (MAPK) as a Potential Therapeutic Target . . . . . . . . . 3. MAPK Pathways . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4. The p38 MAPK Cascade . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4.1 p38 MAPK and its Inhibition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4.2 MAPK/extracellular regulated kinase kinase (MEK) and Upstream Activation of p38 MAPK 4.3 Downstream Effectors of the p38 MAPK Cascade . . . . . . . . . . . . . . . . . . . . . . . . 5. Effect of the p38 MAPK Cascade on Gene Expression . . . . . . . . . . . . . . . . . . . . . . . . . 5.1 Transcriptional Effects of the p38 MAPK . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5.2 Posttranscriptional and Translational Events Are Regulated by p38 MAPK . . . . . . . . . . . 5.3 p38-Dependent Responses May Also Be Inhibitory! . . . . . . . . . . . . . . . . . . . . . . . . 6. The p38 MAPK in Inflammation and Asthma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.1 p38 MAPK in Eosinophils . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.2 p38 MAPK in Airway Epithelial and Goblet Cells . . . . . . . . . . . . . . . . . . . . . . . . . . 6.3 p38 MAPK in Airway Smooth Muscle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.4 p38 MAPK in Endothelial Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.5 p38 MAPK in Mast Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.6 p38 MAPK in Lymphocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.7 p38 MAPK in Monocyte/Macrophage Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.8 p38 MAPK in Neutrophils . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.9 p38 MAPK in Neurogenic Inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.10 p38 MAPK in Vivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7. Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Abstract
. . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . .
Data Loading...
