AMP-activated Protein Kinase
AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including
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Mario D. Cordero Benoit Viollet Editors
AMP-activated Protein Kinase
Experientia Supplementum
Volume 107
More information about this series at http://www.springer.com/series/4822
Mario D. Cordero • Benoit Viollet Editors
AMP-activated Protein Kinase
Editors Mario D. Cordero Oral Medicine Department Universidad de Sevilla Sevilla, Spain
Benoit Viollet INSERM U1016 Institut Cochin CNRS UMR 8104 Universite´ Paris Descartes Paris, France
ISSN 1023-294X Experientia Supplementum ISBN 978-3-319-43587-9 ISBN 978-3-319-43589-3 DOI 10.1007/978-3-319-43589-3
(eBook)
Library of Congress Control Number: 2016955181 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
The survival of all organisms depends on the dynamic control of energy metabolism and the regulation of a plethora of biochemical and molecular processes. The availability or nonavailability of the major cellular energy resource adenosine triphosphate (ATP) determines whether cells may grow and divide or starve and die. Intracellular sensors of cellular energy and nutrient status are emerging as key player in the regulation of cell metabolism in health and disease. Among the different signaling hubs characterized in recent years, adenosine monophosphateactivated protein kinase (AMPK) signaling participates in the maintenance of intracellular ATP levels within an appropriate range. By sensing changes in AMP/ATP and ADP/ATP ratios, AMPK coordinates cellular energy balance by switching on catabolic pathways and switching off ATP-consuming processes at both the cellular and whole-body level. According to the function of AMPK as a master regulator of cell energy levels, it is becoming evident why a dysfunction in the AMPK signaling pathway has been involved directly or indirectly in the derangement of ene
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