Interactive mapping of language and memory with the GE2REC protocol
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ORIGINAL RESEARCH
Interactive mapping of language and memory with the GE2REC protocol Sonja Banjac 1 & Elise Roger 1 & Emilie Cousin 1,2 & Marcela Perrone-Bertolotti 1 & Célise Haldin 1 & Cédric Pichat 1 & Laurent Lamalle 2 & Lorella Minotti 3 & Philippe Kahane 3 & Monica Baciu 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Previous studies have highlighted the importance of considering cognitive functions from a dynamic and interactive perspective and multiple evidence was brought for a language and memory interaction. In this study performed with healthy participants, we present a new protocol entitled GE2REC that interactively accesses the neural representation of language-and-memory network. This protocol consists of three runs related to each other, providing a link between tasks, in order to assure an interactive measure of linguistic and episodic memory processes. GE2REC consists of a sentence generation (GE) in the auditory modality and two recollecting (2REC) memory tasks, one recognition performed in the visual modality, and another one recall performed in the auditory modality. Its efficiency was evaluated in 20 healthy volunteers using a 3T MR imager. Our results corroborate the ability of GE2REC to robustly activate fronto-temporo-parietal language network as well as temporal mesial, prefrontal and parietal cortices in encoding during sentence generation and recognition. GE2REC is useful because it: (a) requires simultaneous and interactive language-and-memory processes and jointly maps their neural basis; (b) explores encoding and retrieval, managing to elicit activation of mesial temporal structures; (c) is easy to perform, hence being suitable for more restrictive settings, and (d) has an ecological dimension of tasks and stimuli. GE2REC may be useful for studying neuroplasticity of cognitive functions, especially in patients with temporal lobe epilepsy who show reorganization of both language and memory networks. Overall, GE2REC can provide valuable information in terms of the practical foundation of exploration language and memory interconnection. Keywords Language . Memory . fMRI mapping . Cognitive interaction
Introduction It is suggested that the base of proper cognitive functioning is the dynamic interaction between different neuropsychological Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11682-020-00355-x) contains supplementary material, which is available to authorized users. * Monica Baciu [email protected] 1
Univ. Grenoble Alpes, CNRS LPNC UMR 5105, F-38000 Grenoble, France
2
Univ. Grenoble Alpes, UMS IRMaGe CHU Grenoble, F-38000 Grenoble, France
3
Univ. Grenoble Alpes, GIN, Synchronisation et modulation des Réseaux Neuronaux dans l’Epilepsie’ and Neurology Department, F-38000 Grenoble, France
domains (Kellermann et al. 2016). Specifically, there is growing evidence suggesting that memory and language influence each other more than previously thought (Huettig and Janse 2016; Mosc
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