Intervention with kimchi microbial community ameliorates obesity by regulating gut microbiota
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Intervention with kimchi microbial community ameliorates obesity by regulating gut microbiota§ Seong-Eun Park1†, Sun Jae Kwon2†, Kwang-Moon Cho2, Seung-Ho Seo1, Eun-Ju Kim1, Tatsuya Unno3, So-Hyeon Bok4, Dae-Hun Park4*, and Hong-Seok Son1* 1
School of Korean Medicine, Dongshin University, Naju, 58245, Republic of Korea 2 AccuGene Inc., Incheon 22006, Republic of Korea 3 Faculty of Biotechnology, School of Life Sciences, SARI Jeju National University, Jeju 63243, Republic of Korea 4 Department of Nursing, Dongshin University, Naju, 58245, Republic of Korea (Received May 20, 2020 / Revised Jul 9, 2020 / Accepted Jul 15, 2020)
The objective of this study was to evaluate anti-obesity effects of kimchi microbial community (KMC) on obesity and gut microbiota using a high fat diet-induced mouse model compared to effects of a single strain. Administration of KMC decreased body weight, adipose tissue, and liver weight gains. Relative content of Muribaculaceae in the gut of the KMCtreated group was higher than that in the high-fat diet (HFD) group whereas relative contents of Akkermansiaceae, Coriobacteriaceae, and Erysipelotrichaceae were lower in KMCtreated group. Metabolic profile of blood was found to change differently according to the administration of KMC and a single strain of Lactobacillus plantarum. Serum metabolites significantly increased in the HFD group but decreased in the KMC-treated group included arachidic acid, stearic acid, fumaric acid, and glucose, suggesting that the administration of KMC could influence energy metabolism. The main genus in KMC was not detected in guts of mice in KMC-treated group. Since the use of KMC has advantages in terms of safety, it has potential to improve gut microbial community for obese people. Keywords: obesity, kimchi microbial community, metabolomics, amplicon sequencing, microbiota Introduction Obesity, a metabolic disorder that is increasing worldwide, has been linked to many health problems such as diabetes, † These authors contributed equally to this work. *For correspondence. (D.H. Park) E-mail: [email protected]; Tel.: +8261-330-3587 / (H.S. Son) E-mail: [email protected]; Tel.: +82-61-330-3513 § Supplemental material for this article may be found at http://www.springerlink.com/content/120956. Copyright ⓒ 2020, The Microbiological Society of Korea
cardiovascular disease, and cancer (Rössner, 2002; Aballay et al., 2013). Although the underlying cause of obesity is an energy imbalance, obesity can also be caused by other factors such as genetics, epigenetic genetics, and intestinal microbial composition (Peters et al., 2018). A recent study has speculated that gut microbiota can influence the effector molecules that determine fat storage in adipocytes, thus affecting host nutrients acquisition and energy homeostasis (Dahiya et al., 2017). Since gut bacterial community can change, it is an attractive candidate for the prevention and treatment of obesity (Peters et al., 2018). In general, obese people have an unbalanced gut microbial
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