Undaria pinnatifida improves obesity-related outcomes in association with gut microbiota and metabolomics modulation in
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APPLIED MICROBIAL AND CELL PHYSIOLOGY
Undaria pinnatifida improves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice Lili Li 1,2 & Yuting Wang 1,2,3 & Jingyi Yuan 1,2,4 & Zhengyi Liu 1,2 & Changqing Ye 3 & Song Qin 1,2 Received: 2 April 2020 / Revised: 27 August 2020 / Accepted: 7 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Dietary fiber has beneficial effects on obesity-related diseases and gut microbiota, contributing a key role in the interaction between dietary metabolism and host metabolism. Our objective was to investigate the cause of the improvement in multiple types of physiological states with seaweed Undaria pinnatifida treatment on high-fat diet-fed mice and to evaluate whether its consequent anti-adiposity and anti-hyperlipidemic effects are associated with gut microbiota and its metabolomics regulation. U. pinnatifida administration in our experiment was shown to significantly decrease high-fat diet-induced body weight gain, as well as epididymal and abdominal adiposity. U. pinnatifida intake also significantly reduced liver weight and serum triacylglycerol accumulation. We also found that improving effects of U. pinnatifida on high-fat diet-induced metabolic dysfunctions were associated with significant increase in specific bacteria, such as Bacteroides acidifaciens and Bacteroides ovatus, as well as metabolites, including short-chain fatty acids and tricarboxylic acid cycle intermediates. Our result provides a cheap dietary strategy to host metabolism improvement and obesity management. Key points • U. pinnatifida improved adipose accumulation and lipid metabolism. • B. acidifaciens and B. ovatus contributed to the beneficial effects of U. pinnatifida. • SCFAs and TCA cycle intermediates were critical to the metabolic outcomes. • Our study provides a cheap dietary strategy for obesity management. Keywords Undaria pinnatifida . Hyperlipidemia . Adiposity . Gut microbiota . Metabolome . High-fat diet
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00253-020-10954-9) contains supplementary material, which is available to authorized users. * Changqing Ye [email protected] * Song Qin [email protected] 1
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
2
Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
3
School of Public Health, Nantong University, Nantong 226019, China
4
College of Life Sciences, Yantai University, Yantai 264005, China
The increased amounts of fat and sugar and decreased addition of dietary fibers are typical lifestyles in western and developed countries. Such lifestyle may at least in part disrupt the microbial ecosystem, contributing to increase risks of chronic inflammatory disease, allergies, and obesity and its related pathologies (Deehan and Walter 2016; Trompette et al. 2014). U. pinnatifida, an important brown seaweed species, is native t
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