Intracellular Ca2+ Regulation
A plethora of cellular functions including vasoconstriction and vasodilatation are regulated by calcium (Ca2+) ion and the cytosolic Ca2+ homeostasis and, therefore, are controlled by various complex yet coordinated mechanisms, in particular considering t
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Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation
Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation
Yuansheng Gao
Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation
Yuansheng Gao Department of Physiology and Pathophysiology Peking University Health Science Center Beijing, China
ISBN 978-981-10-4809-8 ISBN 978-981-10-4810-4 DOI 10.1007/978-981-10-4810-4
(eBook)
Library of Congress Control Number: 2017940986 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
To my dear mentor Professor Paul M. Vanhoutte.
Preface
The discovery that the vascular contractility is regulated by a potent diffusible factor derived from the endothelium made by Furchgott and Zawadzki in 1980 is an epoch-making milestone in vascular biology. For a long time, the endothelium has been largely considered as a selective permeable barrier between the circulating blood and the vascular smooth muscle. Intensive studies evoked by Furchgott and Zawadzki’s work since then have firmly established that the endothelium-derived nitric oxide, prostanoids, endothelin, and endothelium-dependent hyperpolarization play a dominant role in the regulation of vascular activities both under physiological and pathophysiological conditions. Meanwhile, aided by the rapid advances in biology and medical science in particular advance in molecular biology, numerous progresses have been made on the mechanisms underlying the vascular motion, including STIM–Orai protein-mediated store-operated Ca2+ entry, RhoA-Rho kinase signaling, the regulation of myosin light chain phosphatase
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