Intracellular Delivery Fundamentals and Applications
This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanom
- PDF / 27,892,607 Bytes
- 871 Pages / 439.37 x 666.142 pts Page_size
- 85 Downloads / 221 Views
FUNDAMENTAL BIOMEDICAL TECHNOLOGIES Series Editor: Mauro Ferrari, Ph.D. Houston, TX. Volume 1: Martin, Donal. Nanobiotechnology of Biomimetic Membranes. 978-0-387-37738-4. 2006 Volume 2: Cristini, V., M. Ferrari, and P. Decuzzi. Nanoparticulate Delivery to Cancerous Lesions. 978-0-387-29085-0. Forthcoming Volume 3: Bulte, J.W., and Mike Modo. Nanoparticules in Biomedical Imaging. 978-0-387-72026-5. 2007 Volume 4: Vladimir Torchilin. Multifunctional Pharmaceutical Nanocarriers. 978-0-387-76551-8. 2008 Volume 5: Aleš Prokop. Intracellular Delivery: Fundamentals and Applications. 978-94-007-1247-8. 2011
For further volumes: http://www.springer.com/series/7045
Aleš Prokop Editor
Intracellular Delivery Fundamentals and Applications
Editor Aleš Prokop Chemical and Biological Engineering Vanderbilt University VU Station B 351604 37235 Nashville, Tennessee USA [email protected]
ISSN 1559-7083 ISBN 978-94-007-1247-8 e-ISBN 978-94-007-1248-5 DOI 10.1007/978-94-007-1248-5 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011929631 © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
Part I Mechanisms of Uptake and Targeting Mass Transport via Cellular Barriers and Endocytosis.............................. Silvia Ferrati, Agathe K. Streiff, Srimeenakshi Srinivasan, Jenolyn F. Alexander, Nikhil Bhargava, Andrew M. Peters, Nelly E. Song, Ennio Tasciotti, Biana Godin, Mauro Ferrari, and Rita E. Serda Approaches to Achieving Sub-cellular Targeting of Bioactives Using Pharmaceutical Nanocarriers.............................................................. Melani Solomon and Gerard G.M. D’Souza Delivery to Intracellular Targets by Nanosized Particles . .......................... Gillian Barratt The Potential and Current Progress of Internalizing Molecules in Targeted Drug Delivery............................................................................... Jiehua Zhou and John J. Rossi
3
57 73
97
Simulation Based Analysis of Nanocarrier Internalization: Exciting Challenges with a New Computational Tool.................................................. 125 Béla Csukás, Mónika Varga, Aleš Prokop, and Sándor Balogh Nanosized Drug Delivery Vectors and the Reticuloendothelial System............................................................................................................... 155 Lisa M. Kaminskas and Ben J. Boyd Membrane Crossover by Cell-Penetrating Peptides: Kinetics and Mechanisms – From Model to Cell Membrane Perturbation by Permeant Peptides............
