Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patien
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ORIGINAL ARTICLE
Involvement of oral bacteria and oral immunity as risk factors for chemotherapy‑induced fever with neutropenia in patients with hematological cancer Yuka Sogawa1,2 · Makoto Fukui1 · Shingen Nakamura3 · Kimiko Sogabe3 · Ryohei Sumitani3 · Masami Yoshioka2 · Masahiro Abe3 · Daisuke Hinode1 Received: 12 April 2020 / Revised: 12 August 2020 / Accepted: 20 August 2020 © Japanese Society of Hematology 2020
Abstract The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/ μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p
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