Oral delivery of hematopoietic factors
- PDF / 349,978 Bytes
- 13 Pages / 612 x 790.56 pts Page_size
- 57 Downloads / 195 Views
REVIEW ARTICLE
© 2006 Adis Data Information BV. All rights reserved.
Oral Delivery of Hematopoietic Factors Progress with Gastrointestinal Mucoadhesive Patches, Microdevices, and Other Microfabrication Technologies Kanji Takada Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan
Contents Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 1. Conventional Pharmaceutical Technology for Oral Delivery of Hematopoietic Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 2. Absorption Enhancers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 3. Liposomes, Microcapsules and Nanocapsules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 4. Protein-Unfolding Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 5. Protein Conjugates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 6. Colonic Delivery System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 7. Gastrointestinal Mucoadhesive Patch System (GI-MAPS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 8. Fabrication of the GI-MAPS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 9. Carbon Nanotube as an Oral Drug-Delivery System Carrier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 10. Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
Abstract
As a second wave of biopharmaceuticals, oral protein/peptide delivery systems have been studied and applied to hematopoietic factors such as erythropoietin (EPO) and granulocyte colony-stimulating factor (G-CSF). Many conventional oral drug-delivery systems such as absorption enhancers, emulsions, liposomes, microcapsules and nanocapsules, protein-unfolding technology, protein conjugates, and colon delivery technology have been challenged for the development of oral h
Data Loading...
