Irisin is more strongly predicted by muscle oxidative potential than adiposity in non-diabetic men
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ORIGINAL PAPER
Irisin is more strongly predicted by muscle oxidative potential than adiposity in non-diabetic men Claire Huth & Marie-Julie Dubois & André Marette & Angelo Tremblay & S. John Weisnagel & Michel Lacaille & Pascale Mauriège & Denis R. Joanisse
Received: 17 December 2014 / Accepted: 13 March 2015 # University of Navarra 2015
Abstract Numerous controversies surround the peptide hormone irisin. Although implicated as a myokine promoting the browning of adipose tissue in rodents, its roles in humans remain unclear. Contradictory results have also been found with respect to the relationships between adiposity or metabolic health and plasma irisin levels in humans. We investigated the relationship between irisin levels and body composition (hydrostatic weighing), insulin sensitivity (hyperinsulinemiceuglycemic clamp), fitness level (ergocycle VO2max) and skeletal muscle metabolic profile in 53 men (aged 34–53 years) from four groups: sedentary non-obese controls (body mass index [BMI]
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