Ishige okamurae reduces blood glucose levels in high-fat diet mice and improves glucose metabolism in the skeletal muscl
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(2020) 23:24
RESEARCH ARTICLE
Open Access
Ishige okamurae reduces blood glucose levels in high-fat diet mice and improves glucose metabolism in the skeletal muscle and pancreas Hye-Won Yang1†, Myeongjoo Son2,3†, Junwon Choi2,3, Seyeon Oh3, You-Jin Jeon1,4, Kyunghee Byun2,3* and Bo Mi Ryu1,4*
Abstract Brown alga (Ishige okamurae; IO) dietary supplements have been reported to possess anti-diabetic properties. However, the effects of IO supplements have not been evaluated on glucose metabolism in the pancreas and skeletal muscle. C57BL/6 N male mice (age, 7 weeks) were arranged in five groups: a chow diet with 0.9% saline (NFD/saline group), high-fat diet (HFD) with 0.9% saline (HFD/saline group). high-fat diet with 25 mg/kg IO extract (HFD/25/IOE). high-fat diet with 50 mg/kg IO extract (HFD/50/IOE), and high-fat diet with 75 mg/kg IO extract (HFD/ 75/IOE). After 4 weeks, the plasma, pancreas, and skeletal muscle samples were collected for biochemical analyses. IOE significantly ameliorated glucose tolerance impairment and fasting and 2 h blood glucose level in HFD mice. IOE also stimulated the protein expressions of the glucose transporters (GLUTs) including GLUT2 and GLUT4 and those of their related transcription factors in the pancreases and skeletal muscles of HFD mice, enhanced glucose metabolism, and regulated blood glucose level. Our results suggest Ishige okamurae extract may reduce blood glucose levels by improving glucose metabolism in the pancreas and skeletal muscle in HFD-induced diabetes. Keywords: Ishige okamurae, Diabetes, High-fat diet mice, Skeletal muscle, Pancreas
Background Type 2 diabetes is the complex metabolic disorders characterized by an abnormal glucose metabolism arising from pancreatic β-cell dysfunction and glucose intolerance (Hamza et al. 2010, Guilherme et al. 2008, Bell et al. 2001). Glucose metabolism is an essential target to treat type 2 diabetes (Rines et al. 2016, Tsuneki et al. 2004). Controlling blood glucose levels requires the establishment of balance between glucose utilization, * Correspondence: [email protected]; [email protected] † Hye-Won Yang and Myeongjoo Son contributed equally to this work. 2 Department of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon 21565, Republic of Korea 1 Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, 1 Ara 1-dong, Jejudaehak-ro, Jeju 63243, Republic of Korea Full list of author information is available at the end of the article
glucose production, and glucose transport (Giugliano et al. 2008). Previous studies have emphasized adults in a state of glucose intolerance and obesity of children and adolescents are at increased risk of disrupted glucose metabolism (Wiegand et al. 2005). Furthermore, it has been established glucose intolerance and β-cell dysfunction are characteristics of the pathogenesis of impaired glucose metabolism. Hyperglycemia and glucose intolerance are suppressed by improved glucose transport, which is regulated by the GLUT transporter f
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