Kidney Development and Disease
Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as power
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Rachel K. Miller Editor
Kidney Development and Disease
Results and Problems in Cell Differentiation
Volume 60
Series editors Jacek Z. Kubiak, Rennes CX, France Malgorzata Kloc, Houston, TX, USA
More information about this series at http://www.springer.com/series/400
Rachel K. Miller Editor
Kidney Development and Disease
Editor Rachel K. Miller Department of Pediatrics The University of Texas Health Science Center at Houston Houston, Texas USA
ISSN 0080-1844 ISSN 1861-0412 (electronic) Results and Problems in Cell Differentiation ISBN 978-3-319-51435-2 ISBN 978-3-319-51436-9 (eBook) DOI 10.1007/978-3-319-51436-9 Library of Congress Control Number: 2017934474 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
The study of kidney development and maintenance is critical in understanding the progression of human disease. Disruption of renal development can give rise to congenital pathologies including cystic diseases and pediatric kidney cancer. Maintenance of the kidney is critical to prevent renal damage later in life, which may lead to fibrosis and chronic kidney disease (CKD). Current research aimed at understanding kidney development and homeostasis is enabling the field to progress toward regenerative and stem cell therapies to repair damaged nephrons. Our improved imaging capabilities as well as our growing understanding of the molecular mechanisms behind nephrogenesis are leading to novel strategies to generate nephrons de novo as potential treatment for CKD and other renal pathologies. Research in animal models has made substantial contributions to our fundamental understandi
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