Kinetics of Drug Action
Most drugs, toxins, hormones, and the like bring about their biologic actions by reacting with specific receptors somewhere in the body. Scientists working in all areas of biologic science have shown increasing interest in the analysis of drug-receptor in
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H erausgeber Editorial Board G. V. R. Born, Cambridge· o. Eichler, Heidelberg A. Farah, Rensselaer, NY . H. Herken, Berlin
A. D. Welch, Memphis, TN Beirat Advisory Board E. 1. Ari~ns . Z. M. Bacq . P. Calabresi . S. Ebashi . E. G. Erdos V.Erspamer· U.S. von Euler· W.S.Feldberg· G.B.Koelle· O.Krayer T. A. Loomis . H.Raskova· M.Rocha e Silva· F.Sakai· l.R. Vane P.G.Waser· W.Wilbrandt
Kinetics of Drug Action Contributors
1. Blanck· F. G. van den Brink· C. A. M. van Ginneken R. E. Gosselin· P. Th. Henderson· H. C. 1. Ketelaars E. Kriiger-Thiemer . D. Mackay· 1. M. van Rossum W. Scheler· T.B. Vree Editor
Jacques M. van Rossum With 105 Figures
Springer-Verlag Berlin Heidelberg New York 1977
Prof. Dr. JACQUES M. VAN ROSSUM, Katholieke Universiteit Nijmegen, Farmacologisch Instituut, Faculteit der Geneeskunde, Geert Grooteplein Noord 21, Nijmegen, The Netherlands
ISBN-13: 978-3-642-66539-4 e-ISBN-13: 978-3-642-66537-0 001: 10.1007/978-3-642-66537-0
Library of Congress Cataloging in Publication Data. Main entry under title: Kinetics of drug action. (Handbuch der experimentellen Pharmakologie: New series; v. 47) Includes bibliographies and indexes. 1. Pharmacokinetics. 2. Pharmacology, 1. Blanck, J. II. Van Rossum,J.M., 1930---1II. Series. QP905.H3 Bd.47 [RM301.5] 615:1'08s [615:7] 77-8315 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Law where copies are made for other than private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher.
© by Springer-Verlag Berlin· Heidelberg 1977. Softcover reprinl of the hardcover 1sl edition 1977 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. 2122/3130-543210
Dedicated to Dr. Ekkehard Kriiger-Thiemer
Dr. EKKEHARD KRUGER-THIEMER has been a world-leading authority in the field of pharmacokinetics. He was a brilliant intellectual, not only with a broad knowledge in medicine and the natural sciences, but also with a thorough background in cultural sciences. He was a world-leading scientist with a most sympathetic personality. As a young physician he was forced to interrupt his career during World War II and for 5 years thereafter he was deprived of freedom by the Russian state. Finally, once again back in the free world he continued his studies in mathematics which he completed quite successfully in 1954. Dr. KRUGER-THIEMER was appointed to a research position at the Borstel Tuberculosis Research Institute in Northern Germany. Here he combined his broad knowledge in medicine, microbiology, and mathematics for the optimalization of chemotherapy in tuberculosis and other infecti
