Label-free silver triangular nanoplates for spectrophotometric determination of catecholamines and their metabolites
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ORIGINAL PAPER
Label-free silver triangular nanoplates for spectrophotometric determination of catecholamines and their metabolites Valeriy D. Zaytsev 1 & Aleksei A. Furletov 1 & Vladimir V. Apyari 1 Yury A. Zolotov 1,3
&
Alexey V. Garshev 1,2 & Stanislava G. Dmitrienko 1 &
Received: 10 April 2020 / Accepted: 29 September 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract A novel method towards spectrophotometric determination of catecholamines and their metabolites differing in their functional groups has been developed. This method is based on a change in morphology of silver triangular nanoplates upon the action of cateсholamines and their metabolites, which is manifested by the decrease of the nanoparticle local surface plasmon resonance (LSPR) band intensity or its shift to the short-wavelength region of the spectrum. The shift value of the LSPR band or the change of its intensity increases with increasing concentration of catecholamines or their metabolites, which is proposed for their spectrophotometric determination. The limits of detection of catecholamines and their metabolites under selected conditions increase in the series homovanillic acid < vanillylmandelic acid < L-epinephrine < L-norepinephrine < dopamine and are 0.25, 1.2, 3.0, 64, and 130 μmol L−1, respectively. The selectivity of the proposed method was assessed using vanillylmandelic acid as example. It was found that the determination of vanillylmandelic acid does is not interfered in the presence of 4000-fold excess of Na+, K+, CH3COO−, and 1000-fold excess of Mg2+, Ca2+, Al3+, NO3−. The method also allows for the selective determination of vanillylmandelic acid in the presence of a 1000-fold excess of structurally related substances that do not contain either a catechol fragment or an electron donor substituent. The proposed approach was successfully applied to the determination of catecholamines in pharmaceuticals and artificial urine. Keywords Silver triangular nanoplates . Surface plasmon resonance . Spectrophotometry . Catecholamines . Artificial urine analysis . Pharmaceutical analysis
Silver nanoparticles (AgNPs) are widely used in chemical analysis for the determination of different compounds using spectral methods [1, 2]. The localized surface plasmon resonance (LSPR) of AgTNPs results in an absorption band in the visible region of the spectrum that strongly depends on the Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-020-04576-1) contains supplementary material, which is available to authorized users. * Vladimir V. Apyari [email protected] 1
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
2
Department of Materials Science, Lomonosov Moscow State University, Leninskie Gory, 1/73, 119991 Moscow, Russia
3
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy Avenue, 31, 119991 Moscow, Russia
nature, morphology, geometric characteristics, and degree of AgNP
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