Lamotrigine
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Lamotrigine Stevens-Johnson syndrome, hypersensitivity reaction and toxic epidermal necrolysis: 22 case reports
In a retrospective study of 65 patients, 22 patients (9 men and 13 women) aged 6-74 years were described; they developed Stevens-Johnson syndrome, hypersensitivity reaction or toxic epidermal necrolysis after receiving lamotrigine [Lamictal] for epilepsy [dosage, route and time to reactions onset not stated]. All the patients received lamotrigine for a maximum of 8 weeks for epilepsy. However, the patients presented with symptoms like fever, hepatic dysfunction, haematological dysfunction, lymphadenopathy, renal dysfunction or splenomegaly. They developed various severe cutaneous adverse reactions (SCARs). They were diagnosed with hypersensitivity reaction (12 patients), Stevens-Johnson syndrome (9 patients) and toxic epidermal necrolysis (1 patient). The treatment with lamotrigine was discontinued [outcomes not stated]. Kazeem GR, et al. High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients. Pharmacogenetics and Genomics 19: 661-665, No. 803504844 9, Sep 2009. Available from: URL: http://doi.org/10.1097/FPC.0b013e32832c347d
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Reactions 3 Oct 2020 No. 1824
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