Laser-Generated Functional Nanoparticle Bioconjugates Design fo

Annette Barchanski deals with the question how to design nanoparticles for biomedical research. She considers properties such as size, charge, biocompatibility, and functionalization of nanoparticles from a biologist’s point of view in order to achieve sp

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Laser-Generated Functional Nanoparticle Bioconjugates Design for Application in Biomedical Science and Reproductive Biology

Laser-Generated Functional Nanoparticle Bioconjugates

Annette Barchanski

Laser-Generated Functional Nanoparticle Bioconjugates Design for Application in Biomedical Science and Reproductive Biology

Annette Barchanski Laser Zentrum Hannover e.V. Nanotechnology Department Hannover, Germany Dissertation, University of Duisburg-Essen, Faculty of Chemistry, 2015 Date of ­thesis defense: 22.10.2015 1st Assesor: Prof. habil. Dr.-Ing. Stephan Barcikowski, ­University of Duisburg-Essen 2nd Assesor: Prof. Dr. med. vet. Detlef Rath, Friedrich-­Loeffler-Institut, Institut für Nutztiergenetik, Biotechnologie, Neustadt Chairman: Prof. Dr. rer. nat. Sebastian Schlücker, University of Duisburg-Essen.

OnlinePlus material to this book can be available on http://www.springer-gabler.de/978-3-658-13515-7 ISBN 978-3-658-13514-0 ISBN 978-3-658-13515-7 (eBook) DOI 10.1007/978-3-658-13515-7 Library of Congress Control Number: 2016936435 Springer Spektrum © Springer Fachmedien Wiesbaden 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer Spektrum imprint is published by Springer Nature The registered company is Springer Fachmedien Wiesbaden GmbH

What we know is a drop, what we don’t know is an ocean Sir Isaac Newton (1643-1727)

What you get by achieving your goals is not as important as what you become by achieving your goals Henry David Thoreau (1817-1862)

Preface This work was established during my practice as researcher in the workgroup ‘Nanomaterials’ at the Laser Zentrum Hannover e.V. (LZH) where I focused on various national and international cooperations and two main research projects: (I) ‘Functionalized nanoparticles for the sex-specific selection of bovine spermatozoa’ (Masterrind, NBank), aiming for the development of a biocompatible and specific gold nanomarker for the bovine Y-chromosome in cooperation with the F