Leukemia and Related Disorders Integrated Treatment Approaches

From the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia.  It is designed to answer questions about treatment approaches that commonly

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For further volumes: http://www.springer.com/series/7681

Elihu H. Estey



Frederick R. Appelbaum

Editors

Leukemia and Related Disorders Integrated Treatment Approaches

Editors Elihu H. Estey, M.D. Professor of Medicine Division of Hematology University of Washington School of Medicine Member, Fred Hutchinson Cancer Research Center Attending Physician, Seattle Cancer Care Alliance Seattle, WA USA

Frederick R. Appelbaum, M.D. Professor of Medicine Head, Division of Oncology Director, Clinical Research Division Fred Hutchinson Cancer Research Center Executive Director, Seattle Cancer Care Alliance University of Washington School of Medicine Seattle, WA USA

ISBN 978-1-60761-564-4 e-ISBN 978-1-60761-565-1 DOI 10.1007/978-1-60761-565-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011944980 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)

Preface

There is no shortage of multiauthored books describing management of acute and chronic leukemias and myelodysplastic syndromes. However, we believe that this book has several distinctive features. All the authors are members of a single academic center. While the authors’ views on treatment approaches necessarily differ, the book’s single-center nature will hopefully provide the reader with a relatively unified approach to management. This theme is furthered by the inclusion of three chapters on the role of allogeneic transplant, befitting the Fred Hutchinson Cancer Research Center’s long history of leadership in this discipline. There are both chapters on supportive care and on long-term complications of successful treatment, another long-standing interest of the center. The authors’ expertise has prompted the editors to give them wide latitude in writing the chapters. In general, the chapters combine a thorough review of the literature and their own perspec