Levothyroxine sodium
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Congenital cataract following in utero exposure: case report A 30-week-old female fetus developed congenital cataract following in utero exposure to levothyroxine sodium. The mother of the fetus received levothyroxine sodium [maternal dosage and route not stated] for hypothyroidism during pregnancy. A fetal ultrasound performed at 30 weeks and 1 day of gestation indicated opacity of the lens, and a possible congenital cataract was suspected. However, no such image was observed in the subsequent ultrasound performed at 35 weeks and 4 days of gestation. The mother delivered the female neonate at 41 weeks of gestation with a birth weight of 3 680g and Apgar score of 10/9/10. The neonate’s physical examination was normal; however, absence of red reflux in the left eye was noted on day 1. Thereafter, opthalmological evaluation was performed, and an echography revealed poor and irregular dilatation of left eye along with macrophthalmia (15.9mm). Based on these findings, the diagnosis of congenital cataract was confirmed [duration of treatment to reaction onset not stated]. She began regular Neonataology and Ophthalmology visits since the age of 2 months. At her last visit, a total cataract with vascularised membrane was noted; however, surgery was delayed and she remained active surveillance [outcome not stated]. Gorito V, et al. Congenital cataract in the newborn: Report of an early diagnosis. European Journal of Pediatrics 178: 1737-1738 abstr. 519, 23 Nov 2019. Available from: 803503068 URL: http://doi.org/10.1007/s00431-019-03466-w [abstract]
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Reactions 26 Sep 2020 No. 1823
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